Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study

M Mamede, K Ishizu, M Ueda, T Mukai… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated
in various brain functions. They also are thought to play an important role in nicotine …

In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT

M Kassiou, S Eberl, SR Meikle, A Birrell… - Nuclear medicine and …, 2001 - Elsevier
To quantify changes in neuronal nAChR binding in vivo, quantitative dynamic SPECT
studies were performed with 5-[123I]-iodo-A-85380 in baboons pre and post chronic …

Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT

M Mamede, K Ishizu, M Ueda, T Mukai… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human
brain, especially the α4β2 subtype of nAChR. The cholinergic systems have roles in various …

Quantification of smoking-induced occupancy of β2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding

I Esterlis, KP Cosgrove, JC Batis, F Bois… - Journal of Nuclear …, 2010 - Soc Nuclear Med
5-123I-iodo-85380 (123I-5-IA) is used to quantitate high-affinity nicotinic acetylcholine
receptors (β2-nAChRs) on human SPECT scans. The primary outcome measure is VT/f P …

123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase

KP Cosgrove, EM Mitsis, F Bois, E Frohlich… - Journal of Nuclear …, 2007 - Soc Nuclear Med
The study of the effects of sex and hormones on brain chemistry and neurotransmission is of
increasing importance as evidence emerges of sex differences in behavioral symptoms and …

Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease

M Mousavi, E Hellström-Lindahl, ZZ Guan, KR Shan… - Neuroscience, 2003 - Elsevier
The neuronal nicotinic receptors (nAChRs) are involved in several processes in brain
including nicotine dependence and cognitive disorders. While the number of nAChRs in the …

[PDF][PDF] Measurement of α4β2 nicotinic acetylcholine receptors with [123I] 5-IA-85380 SPECT

M Fujita, G Tamagnan, SS Zoghbi… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Nicotinic acetylcholine receptors (nAChRs) play an important role in tobacco dependence
and a potential therapeutic role in neuropsychiatricdisorders such as Alzheimer's …

Smoking upregulates α4β2* nicotinic acetylcholine receptors in the human brain

U Wüllner, D Gündisch, H Herzog, M Minnerop… - Neuroscience …, 2008 - Elsevier
The role of the α4β2* nicotinic acetylcholine receptors (nAChR) in tobacco addiction in
humans is largely unresolved. We visualized brain α4β2* nicotinic acetylcholine receptors of …

Long‐lasting occupancy of central nicotinic acetylcholine receptors after smoking: A PET study in monkeys

H Valette, M Bottlaender, F Dollé… - Journal of …, 2003 - Wiley Online Library
The aim of this study was to compare the degree of occupancy of central nicotinic
acetylcholine receptors (nAChR) in isoflurane anaesthetized baboon brain following …

Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380

AG Mukhin, AS Kimes, SI Chefer… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Assays of human postmortem brain tissue have revealed that smokers have greater
densities of high-affinity nicotinic acetylcholine receptors (nAChRs) in several brain regions …