99mTc (CO) 3-nitrilotriacetic acid: a new renal radiopharmaceutical showing pharmacokinetic properties in rats comparable to those of 131I-OIH

M Lipowska, LG Marzilli, AT Taylor - Journal of Nuclear Medicine, 2009 - Soc Nuclear Med
To develop a 99mTc renal tracer with a capacity to measure effective renal plasma flow
comparable to that of the clinical gold standard 131I-o-iodohippurate (131I-OIH) and …

99mTc (CO) 3 (NTA): a 99mTc renal tracer with pharmacokinetic properties comparable to those of 131I-OIH in healthy volunteers

AT Taylor, M Lipowska, LG Marzilli - Journal of Nuclear Medicine, 2010 - Soc Nuclear Med
Studies in rats showed that the pharmacokinetics of the tricarbonyl core radiopharmaceutical
99mTc (CO) 3-nitrilotriacetic acid, 99mTc (CO) 3 (NTA), were essentially identical to those of …

99mTc (CO) 3 (NTA) and 131I-OIH: comparable plasma clearances in patients with chronic kidney disease

AT Taylor, M Lipowska, H Cai - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
The pharmacokinetics of the tricarbonyl core radiopharmaceutical 99mTc (CO) 3-
nitrilotriacetic acid (99mTc (CO) 3 (NTA)) in rats and subjects with normal renal function are …

Monoanionic 99mTc-tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: radiosynthesis and evaluation as potential renal tubular tracers

M Lipowska, J Klenc, N Jarkas, LG Marzilli… - Nuclear medicine and …, 2017 - Elsevier
Abstract Introduction 99m Tc (CO) 3-nitrilotriacetic acid, 99m Tc (CO) 3 (NTA), is a new renal
tubular agent with pharmacokinetic properties comparable to those of 131 I-OIH but the …

Initial evaluation of new 99mTc (CO) 3 renal imaging agents having carboxyl-rich thioether ligands and chemical characterization of Re (CO) 3 analogues

H He, M Lipowska, AM Christoforou, LG Marzilli… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: The first human studies of a characterized radiopharmaceutical containing
a {99mTc (CO) 3}+ core, Na [99mTc (CO) 3 (LAN)], demonstrated that Na [99mTc (CO) 3 …

Preclinical evaluation of 99mTc (CO) 3-aspartic-N-monoacetic acid, a renal radiotracer with pharmacokinetic properties comparable to 131I-o-iodohippurate

M Lipowska, J Klenc, LG Marzilli… - Journal of Nuclear …, 2012 - Soc Nuclear Med
In an ongoing effort to develop a renal tracer with pharmacokinetic properties comparable to
p-aminohippurate and superior to those of both 99mTc-mercaptoacetyltriglycine and 131I-o …

First evaluation of a 99mTc-tricarbonyl complex, 99mTc (CO) 3 (LAN), as a new renal radiopharmaceutical in humans

M Lipowska, H He, E Malveaux, X Xu… - Journal of Nuclear …, 2006 - Soc Nuclear Med
99mTc-Mercaptoacetyltriglycine (99mTc-MAG3), 99mTc-dd-and ll-ethylene-dicysteine
(99mTc-EC), and 99mTc-mercaptoacetamide-ethylene-cysteine (99mTc-MAEC) contain …

99mTc renal tubular function agents: current status

D Eshima, AR Fritzberg, A Taylor Jr - Seminars in nuclear medicine, 1990 - Elsevier
Orthoiodohippuric (OIH) acid labeled with 131 I is a widely used renal radiopharmaceutical
agent and has been the standard radiopharmaceutical agent for the measurement of …

Technetium-99m (99mTc) mercaptoacetyltriglycine: update on the new 99mTc renal tubular function agent

D Eshima, A Taylor Jr - Seminars in nuclear medicine, 1992 - Elsevier
Technetium-99m (99m Tc) mercaptoacetyltriglycine (MAG 3) is a new renal
radiopharmaceutical that was recently introduced as a 99m Tc-labeled replacement for …

Re (CO) 3 ([18F] FEDA), a novel 18F PET renal tracer: radiosynthesis and preclinical evaluation

M Lipowska, N Jarkas, RJ Voll, JA Nye, J Klenc… - Nuclear medicine and …, 2018 - Elsevier
Introduction Our previous work demonstrated that the 99m Tc renal tracer, 99m Tc (CO) 3
(FEDA)(99m Tc-1), has a rapid clearance comparable in rats to that of 131 I-OIH, the …