PET of aromatase in gastric parietal cells using 11C-vorozole
M Ozawa, K Takahashi, K Akazawa… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Aromatase is a rate-limiting enzyme for estrogen biosynthesis and has been implicated in
pathophysiological states of various diseases via estrogen production. This enzyme is …
pathophysiological states of various diseases via estrogen production. This enzyme is …
Aromatase imaging with [N-methyl-11C] vorozole PET in healthy men and women
A Biegon, DL Alexoff, SW Kim, J Logan… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Aromatase, the last and obligatory enzyme catalyzing estrogen biosynthesis from
androgenic precursors, can be labeled in vivo with 11C-vorozole. Aromatase inhibitors are …
androgenic precursors, can be labeled in vivo with 11C-vorozole. Aromatase inhibitors are …
Imaging of aromatase distribution in rat and rhesus monkey brains with [11C] vorozole
K Takahashi, M Bergström, P Frändberg… - Nuclear medicine and …, 2006 - Elsevier
Aromatase is an enzyme that converts androgens to estrogens and may play a role in mood
and mental status. The aim of this study was to demonstrate that brain aromatase distribution …
and mental status. The aim of this study was to demonstrate that brain aromatase distribution …
11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain
K Takahashi, T Hosoya, K Onoe, H Doi… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Aromatase (an enzyme that converts androgens to estrogens) in the brain is involved in
neuroprotection, synaptic plasticity, and regulation of sexual and emotional behaviors. To …
neuroprotection, synaptic plasticity, and regulation of sexual and emotional behaviors. To …
[HTML][HTML] PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs
K Takahashi, T Hosoya, K Onoe, T Mori, S Tazawa… - Scientific Reports, 2021 - nature.com
Aromatase is an estrogen synthetic enzyme that plays important roles in brain functions. To
quantify aromatase expression in the brain by positron emission tomography (PET), we had …
quantify aromatase expression in the brain by positron emission tomography (PET), we had …
In vivo visualization of aromatase in animals and humans
A Biegon - Frontiers in neuroendocrinology, 2016 - Elsevier
Aromatase catalyzes the last and obligatory step in the biosynthesis of estrogens across
species. In vivo visualization of aromatase can be performed using positron emission …
species. In vivo visualization of aromatase can be performed using positron emission …
Reinvestigation of the synthesis and evaluation of [N-methyl-11C] vorozole, a radiotracer targeting cytochrome P450 aromatase
SW Kim, A Biegon, ZE Katsamanis, CW Ehrlich… - Nuclear medicine and …, 2009 - Elsevier
INTRODUCTION: We reinvestigated the synthesis of [N-methyl-11C] vorozole, a radiotracer
for aromatase, and discovered the presence of an N-methyl isomer which was not removed …
for aromatase, and discovered the presence of an N-methyl isomer which was not removed …
Increase in [11C] vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids
K Takahashi, M Hallberg, K Magnusson, F Nyberg… - …, 2007 - journals.lww.com
In the present study, we investigated the alteration of aromatase expression in the brain by
anabolic androgenic steroid treatment in male rats. The rats were given nandrolone …
anabolic androgenic steroid treatment in male rats. The rats were given nandrolone …
4-(((4-Iodophenyl)methyl)-4H-1,2,4-triazol-4-ylamino)-benzonitrile: A Potential Imaging Agent for Aromatase
J Song, Z Wu, B Wangtrakuldee, SR Choi… - Journal of Medicinal …, 2016 - ACS Publications
Aromatase (CYP19) is a rate-limiting enzyme that catalyzes the biosynthesis of estrogens.
Imaging agents based on aromatase inhibitors (AIs) have been developed for a PET/SPECT …
Imaging agents based on aromatase inhibitors (AIs) have been developed for a PET/SPECT …
Alteration in [11C] vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide
K Takahashi, Y Tamura, Y Watanabe, B Långström… - …, 2008 - journals.lww.com
In a previous study, we demonstrated that androgenic–anabolic steroids increased
aromatase expression in the bed nucleus of stria terminalis and preoptic area in rat brain, as …
aromatase expression in the bed nucleus of stria terminalis and preoptic area in rat brain, as …