A noninvasive method for quantifying cerebral metabolic rate of oxygen by hybrid PET/MRI: validation in a porcine model

L Narciso, T Ssali, L Liu, H Biernaski… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO2) is PET;
however, it is an invasive and complex procedure that also requires correction for …

A non-invasive reference-based method for imaging the cerebral metabolic rate of oxygen by PET/MR: theory and error analysis

L Narciso, T Ssali, H Iida… - Physics in Medicine & …, 2021 - iopscience.iop.org
Positron emission tomography (PET) remains the gold standard for quantitative imaging of
the cerebral metabolic rate of oxygen (CMRO 2); however, it is an invasive and complex …

Quantitative measurement of oxygen metabolic rate in the rat brain using microPET imaging of briefly inhaled 15O-labelled oxygen gas

SH Yee, K Lee, PA Jerabek, PT Fox - Nuclear medicine …, 2006 - journals.lww.com
Objective The quantitative measurement of cerebral metabolic rate of oxygen (CMRO 2) for
rats using positron emission tomography (PET) has been technically difficult. The present …

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and …

N Kudomi, T Hayashi, N Teramoto… - Journal of Cerebral …, 2005 - journals.sagepub.com
Cerebral blood flow (CBF) and rate of oxygen metabolism (CMRO2) may be quantified using
positron emission tomography (PET) with 15O-tracers, but the conventional three-step …

Quantitative evaluation of cerebral blood flow and oxygen metabolism in normal anesthetized rats: 15O-labeled gas inhalation PET with MRI Fusion

T Watabe, E Shimosegawa, H Watabe… - Journal of Nuclear …, 2013 - Soc Nuclear Med
PET with 15O gas has been used for the quantitative measurement of cerebral blood flow
(CBF), cerebral metabolic rate of oxygen (CMRO2), oxygen extraction fraction (OEF), and …

[HTML][HTML] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: a technical review in the era of PET/MRI

AP Fan, H An, F Moradi, J Rosenberg, Y Ishii, T Nariai… - Neuroimage, 2020 - Elsevier
Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and …

H Ito, H Kubo, K Takahashi, KI Nishijima… - Annals of Nuclear …, 2021 - Springer
Objectives Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV),
cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO 2) …

Accuracy of a method using short inhalation of 15O-O2 for measuring cerebral oxygen extraction fraction with PET in healthy humans

N Hattori, M Bergsneider, HM Wu… - Journal of Nuclear …, 2004 - Soc Nuclear Med
PET with short inhalation of 15O-O2 provides regional oxygen extraction fraction (OEF) in a
shorter acquisition time and with less radiation exposure than does the steady-state method …

[HTML][HTML] Verification of a semi-automated MRI-guided technique for non-invasive determination of the arterial input function in 15O-labeled gaseous PET

S Iguchi, Y Hori, T Moriguchi, N Morita… - Nuclear Instruments and …, 2013 - Elsevier
A semi-automated MR-guided technique has been evaluated for non-invasive estimation of
cerebral metabolic rate of oxygen (CMRO2) using the sequential administration of 15O …

Noninvasive quantification of whole‐brain cerebral metabolic rate of oxygen (CMRO2) by MRI

F Xu, Y Ge, H Lu - Magnetic Resonance in Medicine: An Official …, 2009 - Wiley Online Library
Cerebral metabolic rate of oxygen (CMRO2) is an important marker for brain function and
brain health. Existing techniques for quantification of CMRO2 with positron emission …