(S)-IBZM scans allowed the detection of all six cutaneous le sions, five of six superficial
pathologic lymph nodes, four of five pulmonary and one of two hepatic mÃĐtastases. The …

N-(2-diethylaminoethyl)-2-iodobenzamide (BZA2) has been singled out as the most
efficacious melanoma scintigraphy imaging agent. Our work was designed to assess the …

The aim of this prospective study was to assess the diagnostic value of iodine-123-2-
hydroxy-3-iodo-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl) methyl] benzamide (IBZM) whole-body …

The performance of cytotoxic drugs is defined by their selectivity of uptake and action in
tumor tissue. Recent clinical responses achieved by treating metastatic malignant …

The cellular uptake of 11 radioiodinated aminoalkyl-iodobenzamides (ABA) was studied
using cultivated murine melanoma cells (B16/C3). All derivatives showed a high uptake (up …

Melanoma is a neoplasia of dramatically increasing incidence that has a propensity to
spread rapidly. Early detection is fundamental and patient management requires reliable …

Methods: The syntheses and radioiodinationof eight benzamide derivatives are described.
After intravenous injection into C57BI 6-mice subcutaneously transplanted with B16 …

Several radioiodinated N-(dialkylaminoalkyl) benzamides have been used for planar
scintigraphy and single-photon emission computed tomography (SPECT) of melanoma …

Our group has developed a new radiopharmaceutical, 123I-N-(2-diethylaminoethyl)-2-
iodobenzamide (123I-BZA2), a benzamide derivative able to bind to melanin pigment in …

Melanin synthesised in melanoma cells presents a unique target to which the treatment can
be selectively addressed, provided the pigment is recognised by a suitable drug. Methylene …