In vivo quantification of cerebral translocator protein binding in humans using 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] pyridine-3-acetamide …
This study provides the first comprehensive quantification of translocator protein (TSPO)
binding using SPECT and 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] …
binding using SPECT and 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] …
In Vivo Evaluation of 6 Analogs of 11C-ER176 as Candidate 18F-Labeled Radioligands for 18-kDa Translocator Protein
JH Lee, FG Siméon, JS Liow, CL Morse… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
[HTML][HTML] Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers
M Sakata, K Ishibashi, M Imai, K Wagatsuma, K Ishii… - EJNMMI research, 2017 - Springer
Background N, N-di-n-propyl-2-[2-(4-[11 C] methoxyphenyl)-6, 8-dichloroimidazol [1, 2-a]
pyridine-3-yl] acetamide ([11 C] CB184) is a novel selective radioligand for the 18-kD …
pyridine-3-yl] acetamide ([11 C] CB184) is a novel selective radioligand for the 18-kD …
11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain
M Ikawa, TG Lohith, S Shrestha, S Telu… - Journal of Nuclear …, 2017 - Soc Nuclear Med
For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation,
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
Nondisplaceable binding is a potential confounding factor in 11C-PBR28 translocator protein PET studies
GL Laurell, P Plavén-Sigray, A Jucaite… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The PET ligand 11C-PBR28 (N-((2-(methoxy-11C)-phenyl) methyl)-N-(6-phenoxy-3-
pyridinyl) acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In …
pyridinyl) acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In …
Flutriciclamide (18F-GE180) PET: first-in-human PET study of novel third-generation in vivo marker of human translocator protein
Z Fan, V Calsolaro, RA Atkinson… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Neuroinflammation is associated with neurodegenerative disease. PET radioligands
targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of …
targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of …
Synthesis and pharmacological evaluation of [18 F] PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human …
F Mattner, A Katsifis, T Bourdier, C Loc'h… - RSC Medicinal …, 2021 - pubs.rsc.org
Radiopharmaceuticals that target the translocator protein 18 kDa (TSPO) have been
investigated with positron emission tomography (PET) to study neuroinflammation …
investigated with positron emission tomography (PET) to study neuroinflammation …
Mixed-affinity binding in humans with 18-kDa translocator protein ligands
11C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging: a test–retest study
L Feng, P Jensen, G Thomsen… - Journal of Nuclear …, 2017 - Soc Nuclear Med
123I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator
protein (TSPO). TSPO is upregulated in glial cells and used as a measure of …
protein (TSPO). TSPO is upregulated in glial cells and used as a measure of …
Parametric binding images of the TSPO ligand 18F-DPA-714
18F-labeled N, N-diethyl-2-(2-[4-(2-fluoroethoxy) phenyl]-5, 7-dimethylpyrazolo [1, 5-α]
pyrimidine-3-yl) acetamide (DPA-714) is a radioligand for the 18-kDa translocator protein …
pyrimidine-3-yl) acetamide (DPA-714) is a radioligand for the 18-kDa translocator protein …