Imaging reactive oxygen species (ROS) in nonhuman primate brain with [18F] ROStrace
195 Objectives: High levels of reactive oxygen species (ROS) can lead to oxidative stress,
which has been implicated in cancer, cardiovascular, and neurodegenerative diseases …
which has been implicated in cancer, cardiovascular, and neurodegenerative diseases …
In vitro and in vivo PET imaging properties of [18F] KS1, a fluroethoxy ascorbate derivative to track reactive oxygen species in cancer
1056 Objectives: Ascorbate is a water-soluble antioxidant vitamin. Emerging clinical studies
have used ascorbate as a cancer chemotherapeutic agent, and to ameliorate chemotherapy …
have used ascorbate as a cancer chemotherapeutic agent, and to ameliorate chemotherapy …
Correlation analysis of [18F] ROStrace using ex vivo autoradiography and dihydroethidium fluorescent imaging in lipopolysaccharide-treated animals
Reactive oxygen species (ROS) are believed to play an important role in the
proinflammatory form of neuroinflammation. Therefore, the availability of a radiotracer …
proinflammatory form of neuroinflammation. Therefore, the availability of a radiotracer …
Synthesis, Characterization, and Biochemical Validation of a Novel PET reporter probe for Imaging Reactive Oxygen Species (ROS)-Mediated Inflammation in the …
P1303 Introduction: Oxidative imbalance mediates pathogenesis of amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD) and is known to …
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD) and is known to …
Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system
AA Wilson, O Sadovski, JN Nobrega… - Nuclear Medicine and …, 2017 - Elsevier
Introduction Few, if any, radiotracers are available for the in vivo imaging of reactive oxygen
species (ROS) in the central nervous system. ROS play a critical role in normal cell …
species (ROS) in the central nervous system. ROS play a critical role in normal cell …
Initial biological evaluations of [18F] KS1, novel ascorbate derivative to image oxidative stress in cancer
543 Objectives: Excessive production of reactive oxygen species (ROS) and/or reactive
nitrogen species (RNS) in the tumor microenvironment, through either endogenous or …
nitrogen species (RNS) in the tumor microenvironment, through either endogenous or …
Initial biological evaluations of [18F] KS1, ascorbate-based ROS imaging ligand in tumor models of non-human primates.
N Damuka, G Dugan, A Davis, BL Pathirannahel… - 2021 - Soc Nuclear Med
1480 Objectives: Ascorbic acid is a potent, biological antioxidant. It scavenges most reactive
oxygen species (ROS) that could otherwise damage nucleic acids and promote …
oxygen species (ROS) that could otherwise damage nucleic acids and promote …
Development of a positron emission tomography radiotracer for imaging elevated levels of superoxide in neuroinflammation
C Hou, CJ Hsieh, S Li, H Lee, TJ Graham… - ACS chemical …, 2017 - ACS Publications
Reactive oxygen species (ROS) are believed to play a major role in the proinflammatory, M1-
polarized form of neuroinflammation. However, it has been difficult to assess the role of ROS …
polarized form of neuroinflammation. However, it has been difficult to assess the role of ROS …
Advances in imaging reactive oxygen species
Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can be
either beneficial or harmful. The design of ROS-sensitive fluorophores has allowed for …
either beneficial or harmful. The design of ROS-sensitive fluorophores has allowed for …
Advances in Reactive Oxygen Species (ROS) Imaging
N Murthy, EM Espinoza, JJ Roeise, IC Li… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can
either be beneficial or harmful. Design of ROS sensitive fluorophores has allowed for …
either be beneficial or harmful. Design of ROS sensitive fluorophores has allowed for …