Alterations of free fatty acid (FA) metabolism in several organs are implicated in the
pathogenesis of chronic disorders. The aim of this study was to investigate the …

Purpose The aim of this study was to determine the effect of hyperinsulinemia on myocardial
and hepatic distribution and metabolism of 14 (R, S)-[18 F] fluoro-6-thia-heptadecanoic acid …

14 (R, S)-[18 F] Fluoro-6-thia-heptadecanoic acid ([18 F] FTHA) is a long-chain fatty acid
substrate for fatty acid metabolism.[18 F] FTHA has been used to study fatty acid metabolism …

Introduction Imaging fatty acid uptake and utilization has broad impact in investigating
myocardial diseases, hepatic functions, tumor progression, and the metabolic state of …

Background Fatty acids derived de novo or taken up from the extracellular space are an
essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including …

Increased delivery of circulating free fatty acids (FFA) to the liver has been implicated in the
pathogenesis and progression of diabetes. The liver is inaccessible for direct measurement …

Fatty acid oxidation (FAO) is a major energy-providing process with important implications in
cardiovascular, oncologic, neurologic, and metabolic diseases. A novel 4-thia oleate analog …

This study describes the radiosynthesis and preliminary biologic evaluation of trans-9 (RS)-
18F-fluoro-3, 4 (RS, RS)-methyleneheptadecanoic acid (18F-FCPHA) as a new potential …

INTRODUCTION: 13C, 18F and 123I fatty acids (FA) are used for myocardial imaging.
Recently, our group showed that [99mTc]-labeled “4+ 1” FA are extracted into the rat and …

A noninvasive method to determine postprandial fatty acid tissue partition may elucidate the
link between excess dietary fat and type 2 diabetes. We hypothesized that the positron …