Comparison of two radioligands for PET imaging of translocator protein in human brain: 11C-PBR28 and 18F-PBR06
L Dickstein, S Zoghbi, Y Fujimura, M Imaizumi, Y Zhang… - 2010 - Soc Nuclear Med
554 Objectives Translocator protein (TSPO) is over expressed in activated microglia and is,
therefore, a marker for neuroinflammation. The purpose of this study was to assess the …
therefore, a marker for neuroinflammation. The purpose of this study was to assess the …
Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, 18F-PBR06
Y Fujimura, SS Zoghbi, FG Simeon… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Translocator protein (TSPO)(18 kDa), formerly called the peripheral benzodiazepine
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …
In Vivo Evaluation of 6 Analogs of 11C-ER176 as Candidate 18F-Labeled Radioligands for 18-kDa Translocator Protein
JH Lee, FG Siméon, JS Liow, CL Morse… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation
[11C] PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a
specific binding signal in approximately 14% of healthy volunteers. This phenomenon has …
specific binding signal in approximately 14% of healthy volunteers. This phenomenon has …
Radiation dosimetry of the translocator protein ligands [18F] PBR111 and [18F] PBR102
JD Verschuer, J Towson, S Eberl, A Katsifis… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: The translocator protein (TSPO) ligands [18F] PBR111 and [18F] PBR102
show promise for imaging neuroinflammation. Our aim was to estimate the radiation dose to …
show promise for imaging neuroinflammation. Our aim was to estimate the radiation dose to …
Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
CH Lyoo, M Ikawa, JS Liow, SS Zoghbi… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
[HTML][HTML] In vivo evaluation of a novel 18F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain
X Yan, FG Siméon, JS Liow, CL Morse… - European Journal of …, 2023 - Springer
Abstract Purpose [18F] SF51 was previously found to have high binding affinity and
selectivity for 18 kDa translocator protein (TSPO) in mouse brain. This study sought to …
selectivity for 18 kDa translocator protein (TSPO) in mouse brain. This study sought to …
[PDF][PDF] COMMENTARY Open Access
M Fujita, M Kobayashi, M Ikawa, RN Gunn… - 2017 - ejnmmires.springeropen.com
Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-
PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of …
PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of …
Mixed-affinity binding in humans with 18-kDa translocator protein ligands
11C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding
PET is used to image active inflammatory processes by targeting the translocator protein
(TSPO). In vitro, second-generation TSPO radioligands, such as PBR111, have been shown …
(TSPO). In vitro, second-generation TSPO radioligands, such as PBR111, have been shown …