Amyloid-β (Aβ) deposition is a pathologic hallmark of Alzheimer disease (AD). Although the
typical spatial distribution pattern of Aβ deposition in early AD mainly involves regions …

In PET studies of patients with Alzheimer disease (AD), prominent hypometabolism can
occur in brain regions without major amyloid load. These hypometabolism-only (HO) areas …

Objective: To investigate whether global and regional β-amyloid (Aβ) burden as measured
with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy …

Alzheimer disease (AD) neuropathologic changes are β-amyloid (Aβ) deposition, pathologic
tau, and neurodegeneration. Dual-phase amyloid PET might be able to evaluate Aβ …

Purpose Similar regional anatomical distributions were reported for fibrillary amyloid
deposition [measured by 11 C-Pittsburgh compound B (PIB) positron emission tomography …

Knowledge about spatial and temporal patterns of β-amyloid (Aβ) accumulation is essential
for understanding Alzheimer disease (AD) and for design of antiamyloid drug trials. Here, we …

PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or
blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the …

Purpose Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's
disease (AD) is thought to arise in part due to AD-specific neuronal damage to the …

Inverse correlations between amyloid-β (Aβ) load measured by Pittsburgh Compound-B
(PiB) positron emission tomography (PET) and cerebral metabolism using [18F] fluoro-2 …

ABSTRACT INTRODUCTION In Alzheimer's disease (AD), early diagnosis facilitates
treatment options and leads to beneficial outcomes for patients, their carers and the …