Quantitative imaging of estrogen receptor expression in breast cancer with PET and 18F-fluoroestradiol

LM Peterson, DA Mankoff, T Lawton… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The PET compound 18F-fluoroestradiol (18F-FES) has been developed and tested as an
agent for the imaging of estrogen receptor (ER) expression in vivo. 18F-FES uptake has …

The assessment of estrogen receptor status and its intratumoral heterogeneity in patients with breast cancer by using 18F-fluoroestradiol PET/CT

Z Yang, Y Sun, X Xu, Y Zhang, J Zhang… - Clinical nuclear …, 2017 - journals.lww.com
Aim The aim of this study was to investigate the clinical value of 18 F-fluoroestradiol (18 F-
FES) PET/CT in the assessment of the estrogen receptor (ER) and its intratumoral …

The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F] fluoroestradiol (FES), a PET radiotracer …

JA Katzenellenbogen - Nuclear medicine and biology, 2021 - Elsevier
Abstract Introduction 16α-[18 F] Fluoroestradiol (FES), a PET radiotracer for the estrogen
receptor (ER) in breast cancer, was the first receptor-targeted PET radiotracer for oncology …

Recommendations and technical aspects of 16α-[18F] fluoro-17β-estradiol PET to image the estrogen receptor in vivo: the Groningen experience

CM Venema, G Apollonio, GAP Hospers… - Clinical nuclear …, 2016 - journals.lww.com
The estrogen derivative 16α-18 F-fluoro-17β-estradiol (FES) is a PET tracer that has been
used in a variety of preclinical and clinical studies to detect estrogen receptor (ER) …

PET imaging of estrogen receptors as a diagnostic tool for breast cancer patients presenting with a clinical dilemma

M van Kruchten, AWJM Glaudemans… - Journal of Nuclear …, 2012 - Soc Nuclear Med
16α-18F-fluoro-17β-estradiol (18F-FES) is an estrogen receptor (ER)–specific PET tracer
with various potential interesting applications. The precise contribution of this technique in …

[18F] fluoroestradiol radiation dosimetry in human PET studies

DA Mankoff, LM Peterson, TJ Tewson… - Journal of Nuclear …, 2001 - Soc Nuclear Med
[18F] 16α-fluoroestradiol (FES) is a PET imaging agent useful for the study of estrogen
receptors in breast cancer. We estimated the radiation dosimetry for this tracer using data …

18F-fluoroestradiol PET: current status and potential future clinical applications

GJ Liao, AS Clark, EK Schubert… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Estrogen receptor (ER) expression in breast cancer is associated with a more favorable
prognosis and is necessary for a response to endocrine therapies. Traditionally, ER …

Between-patient and within-patient (site-to-site) variability in estrogen receptor binding, measured in vivo by 18F-fluoroestradiol PET

BF Kurland, LM Peterson, JH Lee… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Heterogeneity of estrogen receptor (ER) expression may be an important predictor of breast
cancer therapeutic response. 18F-fluoroestradiol PET produces in vivo quantitative …

Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer

LM Peterson, BF Kurland, JM Link, EK Schubert… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: 18F-Fluoroestradiol (FES) PET imaging provides a non-invasive method
to measure estrogen receptor (ER) expression in tumors. Assessment of factors that could …

A Phase 2 Study of 16α-[18F]-fluoro-17β-estradiol Positron Emission Tomography (FES-PET) as a Marker of Hormone Sensitivity in Metastatic Breast Cancer (MBC)

LM Peterson, BF Kurland, EK Schubert, JM Link… - Molecular imaging and …, 2014 - Springer
Abstract Purpose 16α-[18 F]-fluoro-17β-estradiol positron emission tomography (FES-PET)
quantifies estrogen receptor (ER) expression in tumors and may provide diagnostic benefit …