Detection of increased 64Cu uptake by human copper transporter 1 gene overexpression using PET with 64CuCl2 in human breast cancer xenograft model

KI Kim, SJ Jang, JH Park, YJ Lee, TS Lee… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Copper is an essential cofactor for a variety of biochemical processes including oxidative
phosphorylation, cellular antioxidant activity, and elimination of free radicals. The copper …

Reduced 64Cu uptake and tumor growth inhibition by knockdown of human copper transporter 1 in xenograft mouse model of prostate cancer

H Cai, J Wu, O Muzik, JT Hsieh, RJ Lee… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Copper is an element required for cell proliferation and angiogenesis. Human prostate
cancer xenografts with increased 64Cu radioactivity were visualized previously by PET …

PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2

F Peng, X Lu, J Janisse, O Muzik… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Our objective was to determine whether human prostate cancer xenografts in mice can be
localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing …

Theranostics of malignant melanoma with 64CuCl2

C Qin, H Liu, K Chen, X Hu, X Ma, X Lan… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Human copper transporter 1 (CTR1) is overexpressed in a variety of cancers. This study
aimed to evaluate the use of 64CuCl2 as a theranostic agent for PET and radionuclide …

Recent Advances in Cancer Imaging with 64CuCl2 PET/CT

F Peng - Nuclear Medicine and Molecular Imaging, 2022 - Springer
Copper is required for cancer cell proliferation and tumor angiogenesis. Radioactive copper-
64 chloride (64CuCl2) is a useful radiotracer for cancer imaging with position emission …

Positron emission tomography of human hepatocellular carcinoma xenografts in mice using copper (II)-64 chloride as a tracer

H Zhang, H Cai, X Lu, O Muzik, F Peng - Academic radiology, 2011 - Elsevier
RATIONALE AND OBJECTIVES: The aim of this study was to assess copper metabolism of
human hepatocellular carcinoma (HCC) with positron emission tomographic (PET) imaging …

High tumor uptake of 64Cu: implications for molecular imaging of tumor characteristics with copper-based PET tracers

JT Jørgensen, M Persson, J Madsen, A Kjær - Nuclear medicine and …, 2013 - Elsevier
INTRODUCTION: The use of copper-based positron emission tomography (PET) tracers in
cancer studies is increasing. However, as copper has previously been found in high …

[HTML][HTML] Pilot Study of 64Cu(I) for PET Imaging of Melanoma

L Jiang, Y Tu, X Hu, A Bao, H Chen, X Ma, T Doyle… - Scientific reports, 2017 - nature.com
Abstract At present, 64Cu (II) labeled tracers including 64CuCl2 have been widely applied in
the research of molecular imaging and therapy. Human copper transporter 1 (hCTR1) is the …

Mouse extrahepatic hepatoma detected on MicroPET using copper (II)-64 chloride uptake mediated by endogenous mouse copper transporter 1

F Peng, J Liu, J Wu, X Lu, O Muzik - Molecular Imaging and Biology, 2005 - Springer
Purpose This study was conducted to assess the positron-emitting copper (II)-64 chloride
(64 CuCl 2) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper …

Expression of the human copper influx transporter 1 in normal and malignant human tissues

AK Holzer, NM Varki, QT Le… - … of Histochemistry & …, 2006 - journals.sagepub.com
The major copper influx transporter, copper transporter 1 (hCTR1), controls the cellular
accumulation of cisplatin in mammalian cells. The goal of this study was to determine the …