Departments ofRadiology, Radiation Oncology, and Pathology, University ofAlabama at
Birmingham, Birmingham, Alabama for mammalian thymidine kinase 1, 3'-deoxy-3'-['8F] …

Utilization of molecular biology techniques offers attractive options in nuclear medicine for
improving cancer imaging and therapy with radiolabeled peptides. Two of these options …

A model epitope-tagged receptor was constructed by fusing the hemagglutinin (HA)
sequence on the extracellular N-terminus of the human somatostatin receptor subtype 2 …

PURPOSE: To compare two systems for assessing gene transfer to cancer cells and
xenograft tumors with noninvasive gamma camera imaging. MATERIALS AND METHODS: A …

Gene therapy trials would benefit greatly from the use of noninvasive imaging to determine
the location, magnitude, and time course of gene transfer. Somatostatin receptor subtype 2 …

Reporter genes (eg β-galactosidase, chloramphenicol-acetyltransferase, green fluorescent
protein, luciferase) play critical roles in investigating mechanisms of gene expression in …

PURPOSE: To assess whether a combination of functional (planar imaging and single
photon emission computed tomography [SPECT]) and anatomic (magnetic resonance [MR] …

A variety of imaging technologies is being investigated as tools for studying gene expression
in living subjects. Two technologies that use radiolabeled isotopes are single photon …

Rapid advances in imaging technologies and gene transfer strategies offer a great
opportunity to optimize clinical trials of human gene therapy. Reporter genes are emerging …

The human somatostatin receptor subtype 2A (hSSTr2) is under evaluation as a reporter
gene for molecular imaging applications. Two approved somatostatin analogues are already …