894 Objectives: The MDMA is a popular illicit drug that produces toxic effect to brain
serotonin neurons. We recently reported that 4-18 F-ADAM (1) is a potent serotonin …

3, 4-Methylenedioxymethamphetamine (MDMA,“ecstasy”) has toxic effects on serotonergic
neurons in the brain. Our aim was to determine whether N, N-dimethyl-2-(2-amino-4-[18F] …

1138 Objectives: N, N-Dimethyl-2-(2-amino-4-[18F]-fluorophenylthio) benzylamine (4-18F-
ADAM) is a novel radiotracer for in vivo imaging of serotonin transporter (SERT). In this …

1322 Objectives: Serotonin transporter (SERT) has been implicated in several
neuropsychiatric disorders. We recently reported that N, N-dimethyl-2-(2-amino-4-[18 F] …

1140 Objectives: We recently reported that N, N-Dimethyl-2-(2-amino-4-[18F]-
fluorophenylthio) benzylamine (4-18F-ADAM) is a potential SERT imaging agent. In this …

There has been considerable interest in the development of a PET radioligand selective for
the serotonin (5-hydroxytryptamine [5-HT]) transporter (SERT) that can be used to image 5 …

Abstract Purpose 4-[18 F]-ADAM is a potent serotonin transport imaging agent. We studied
its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken …

1191 Objectives: Serotonin transporters (SERT) play a major role in modulating serotonergic
neuronal function. The study was undertaken to image central SERT using 18F-ADAM PET …

Background Imaging serotonin transporters during antidepressant treatment in small
animals is a useful tool for preclinical study during drug development. In this work, we aimed …

Background Numerous studies have confirmed that 3, 4-Methylenedioxymethamphetamine
(MDMA) produces long-lasting changes to the serotonergic system and decreases the …