This article gives an update on nigrostriatal dopamine terminal imaging, with emphasis on
SPECT performed with the presynaptic dopamine transporter (DAT) ligand 123I-FP-CIT. The …

Abstract [123 I] FP-CIT (N-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl} nortropane)
has been developed successfully as a radioligand for single-photon emission tomography …

OBJECTIVES: The main neuropathological feature in Parkinson's disease is a severe
degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of …

The functional imaging technique most widely used in European clinics to differentiate a true
parkinsonian syndrome from vascular parkinsonism, drug-induced changes, or essential …

The clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially
in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the …

Aims: Definition of the regional pattern of dopamine transporter (DAT) dysfunction in
advanced Parkinson's disease (PD) and evaluation of a potential correlation between DAT …

As we defeat infectious diseases and cancer, one of the greatest medical challenges facing
us in the mid-21st century will be the increasing prevalence of degenerative disease. Those …

The diagnosis of Parkinson's disease is based on clinical features with pathological
verification. However, autopsy has been found to confirm a specialist diagnosis in only about …

Purpose The aim of this study was to evaluate, by means of 123 I-FP-CIT SPECT, the effect
of chronic treatment with levodopa on striatal dopamine transporter (DAT) in patients with …

Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by
dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers …