REPLY: Dr. Machulla suggests modifications of tracer imaging approaches to the clinical
investigation of Ab-amyloid deposition in dementia. He suggests the potential value of two …

TO THE EDITOR: The development and application of ligands for PET imaging of Alzheimer
disease (AD) has evolved into an important tool for the clinical diagnosis of AD. Among the …

Dear readers, Amyloid imaging by PET to portray the presence of fibrillar Aβ pathology in the
brain may facilitate more accurate diagnosis of dementias and may help in determining …

1009 Attempts for in vivo imaging of Aβ-amyloid (Αβ) plaques were initiated more than 2
decades ago and recently tau protein imaging has been proposed to enhance its sensitivity …

There is mounting evidence and enthusiasm for molecular imaging contribution to the
diagnosis of neurodegenerative dementia. A key advance in the imaging field has been the …

Purpose The aim of this study was to evaluate the longitudinal changes in [11 C] PIB uptake
in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up …

Arecent meeting convened by the US Food and Drug Administration (FDA) provides
optimism for the introduction of new molecular imaging agents for clinical use, particularly for …

ALTHOUGH DISAGREEMENT ABOUT THE ROLE that the ß-amyloid (Aß) protein plays in
Alzheimer disease (AD) abounds, it con-tinues to occupy a central position in both theories …

1174 Objectives: Amyloid deposition, as determined by PET images of specific PIB binding,
has been observed in substantial numbers of non-demented older persons. We compared …

NEWSLINE ologic assays at autopsy,''was presented by Mintun et al.[387] from Washington
University (St. Louis, MO), representing the members of the AV-45-A07 Study Group. In this …