This study sought to determine brain nicotine kinetics from use of the increasingly popular
electronic cigarette (E-cig). Methods: In 17 E-cig users (9 men and 8 women), brain uptake …

Brain accumulation rate and magnitude are critical for the acute reinforcing effects of
nicotine. Despite electronic cigarettes'(E-cigs) appeal as substitutes for traditional …

Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering
aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible …

Abstract Background Electronic cigarettes (ECs) can influence nicotine addiction by
delivering aerosolized nicotine. We investigated if nicotine from ECs is delivered to the brain …

This study assessed the in vivo distribution of 11C-nicotine and the absorbed radiation dose
from whole-body 11C-nicotine PET imaging of 11 healthy (5 male and 6 female) subjects …

Introduction Based on our preliminary 11C-nicotine positron emission tomography (PET)
imaging studies in humans, we speculated that greater deposition of nicotine in the …

Rationale Variation in the rate at which drugs reach the brain influences many different drug
effects and is also thought to influence liability to addiction. For example, rapid intravenous …

Background Although both men and women use e-cigarettes, most preclinical nicotine
research has focused on its effects in male rodents following injection. The goals of the …

Background: Electronic cigarettes (e-cig) known as electronic nicotine devices recently
gained popularity among smokers. Despite many studies investigating their safety and …

Tobacco smoking is a chronic, relapsing disorder that constitutes one of the primary
preventable causes of death in developed countries. Two of the popular hypotheses to …