Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor.
This aggressiveness is in part attributed to the closely interrelated phenomena tumor …

Glioblastoma multiforme is a primary brain tumor known for its rapid proliferation, diffuse
invasion, and prominent neovasculature and necrosis. This study explores the in vivo link …

Purpose: Structural and functional alterations in tumor vasculature are thought to contribute
to tumor hypoxia which is a primary driver of malignancy through its negative impact on the …

Purpose Glioblastoma multiforme (GBM) is characterized by tissue hypoxia associated with
resistance to radiotherapy and chemotherapy. To clarify the biological link between hypoxia …

Purpose Hypoxia in gliomas is associated with tumor resistance to radio-and chemotherapy.
However, positron emission tomography (PET) imaging of hypoxia remains challenging, and …

INTRODUCTION: No direct proof has been brought to light in a link between hypoxic
changes in glioma models and the effects of antiangiogenic treatments. Here, we assessed …

Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …

Purpose: Hypoxia is associated with resistance to radiotherapy and chemotherapy and
activates transcription factors that support cell survival and migration. We measured the …

Purpose: To quantitatively study the spatial distribution of tumor hypoxia in relation to the
perfused vasculature. Methods and Materials: Using a human glioma xenograft model, nude …

Advances in molecular imaging are rapidly changing the paradigm for noninvasive
diagnostic imaging from largely morphologic methods to ones that include both anatomy …