18F-Nifrolene-microPET studies of nicotinic α4β2 receptors
K Vu, E Sevrioukov, C Constantinescu, ML Pan… - 2010 - Soc Nuclear Med
219 Objectives Imaging thalamic and extrathalamic nicotinic α4β2 receptors is important to
study tobacco dependence, cognitive deficits in Alzheimer's disease and other brain …
study tobacco dependence, cognitive deficits in Alzheimer's disease and other brain …
18F-Nifrolene: A new PET imaging agent for α4β2 nAChR nicotinic receptors
R Pichika, B Easwaramoorthy, D Collins, S Potkin… - 2006 - Soc Nuclear Med
76 Objectives: Nicotinic α 4 β 2 receptors are implicated in Alzheimer's disease,
schizophrenia, substance abuse and other disorders. We have developed putative …
schizophrenia, substance abuse and other disorders. We have developed putative …
Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and Biological Evaluation of 3-(2-(S)-3, 4-dehydropyrrolinyl methoxy)-5-(3′-18F-Fluoropropyl) pyridine …
R Pichika, SA Kuruvilla, N Patel, K Vu, S Sinha… - Nuclear medicine and …, 2013 - Elsevier
Imaging agents for nicotinic α4β2 receptors in the brain have been under way for studying
various CNS disorders. Previous studies from our laboratories have reported the successful …
various CNS disorders. Previous studies from our laboratories have reported the successful …
[HTML][HTML] Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging
R Kant, CC Constantinescu, P Parekh, SK Pandey… - EJNMMI research, 2011 - Springer
MicroPET imaging studies using 18 F-nifene, a new positron emission tomography (PET)
radiotracer for nicotinic acetylcholinergic receptors (nAChR) α4β2 receptors in rats, have …
radiotracer for nicotinic acetylcholinergic receptors (nAChR) α4β2 receptors in rats, have …
[HTML][HTML] Synthesis and evaluation of 2-18F-fluoro-5-iodo-3-[2-(S)-3, 4-dehydropyrrolinylmethoxy] pyridine (18F-niofene) as a potential imaging agent for nicotinic α4β2 …
SA Kuruvilla, AT Hillmer, DW Wooten… - American journal of …, 2014 - ncbi.nlm.nih.gov
Nicotinic α4β2 acetylcholine receptors (nAChRs) have been implicated in various
pathophysiologies including neurodegenerative diseases. Currently, 2-18 F-A85380 (2-FA) …
pathophysiologies including neurodegenerative diseases. Currently, 2-18 F-A85380 (2-FA) …
Synthesis and evaluation of nicotine α4β2 receptor radioligand, 5-(3′-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy) pyridine, in rodents and PET in nonhuman …
S Chattopadhyay, B Xue, D Collins… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Nicotine α4β2 receptor subtypes are implicated in the study of Alzheimer's disease,
schizophrenia, substance abuse, lung cancer, and other disorders. We report the …
schizophrenia, substance abuse, lung cancer, and other disorders. We report the …
Nicotinic α4β2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F] fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine (18F-nifene) in rodents …
R Pichika, B Easwaramoorthy, D Collins… - Nuclear medicine and …, 2006 - Elsevier
The α4β2 nicotinic acetylcholine receptor (nAChR) has been implicated in various
neurodegenerative diseases. Optimal positron emission tomography (PET) imaging agents …
neurodegenerative diseases. Optimal positron emission tomography (PET) imaging agents …
Measurement of brain and plasma metabolites of 18F-Nifene
B Easwaramoorthy, R Pichika, C Constantinescu… - 2008 - Soc Nuclear Med
566 Objectives: 2-[18 F] Fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine, 18F-Nifene, is a
new tracer for the α4β2 nicotinic acetylcholine receptors, with faster binding profile in …
new tracer for the α4β2 nicotinic acetylcholine receptors, with faster binding profile in …
PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of 18F-nifene kinetics in the nonhuman primate
AT Hillmer, DW Wooten, MS Slesarev… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The PET radioligand 2-fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine (18F-nifene) is an
α4β2* nicotinic acetylcholine receptor (nAChR) agonist developed to provide accelerated in …
α4β2* nicotinic acetylcholine receptor (nAChR) agonist developed to provide accelerated in …
New Precursor in Improved 18F-Nifene Synthesis for Imaging Nicotinic Receptors
I Patel, C Liang, J Mukherjee - 2016 - Soc Nuclear Med
1086 Objectives The α4β2 nicotine acetylcholine receptor (nAChR) has been implicated in
various neurodegenerative diseases. 18F-Nifene has demonstrated useful properties in …
various neurodegenerative diseases. 18F-Nifene has demonstrated useful properties in …