Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat
(4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive …

In recent years in vivo visualization of tau deposits has become possible with various PET
radiotracers. The tau tracer [18 F] PI-2620 proved high affinity both to 3-repeat/4-repeat tau …

Primary four-repeat tauopathies are characterized by depositions of the four-repeat isoform
of the microtubule binding protein, tau. The two most common sporadic four-repeat …

Tau aggregates represent a key pathologic feature of Alzheimer's disease and other
neurodegenerative diseases. Recently, PET probes have been developed for in vivo …

Background and Objective: Tau-specific positron emission topography (PET) imaging
enables in vivo assessment of Alzheimer's disease (AD). We aimed to investigate its …

Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding
patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently …

Objective 18 F-flortaucipir (formerly 18 F-AV1451 or 18 F-T807) binds to neurofibrillary
tangles in Alzheimer's disease (AD), but tissue studies assessing binding to tau aggregates …

Objective 18F‐flortaucipir (formerly 18F‐AV1451 or 18F‐T807) binds to neurofibrillary
tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in …

Tau PET has enabled the visualization of paired helical filaments of 3 or 4 C-terminal repeat
tau in Alzheimer disease (AD), but its ability to detect aggregated tau in frontotemporal lobar …

Background and purpose Visualization of pathogenic protein aggregates is crucial to
elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative …