Radiosynthesis and in vitro evaluation of [11C] Shield-1, a PET probe for imaging CAR T cells that express the iCasp9 suicide gene
61 Objectives: Recently, T cells engineered with chimeric antigen receptors (CARs) that
target tumor-associated antigens have shown striking activity in a variety of malignancies …
target tumor-associated antigens have shown striking activity in a variety of malignancies …
648. Mitigating Tumor Escape: Tandem Anti-CD20-and CD19 SCFV-Based Chimeric Antigen Receptors (CARs) in Leukemia/Lymphoma
Y Xiong, D Wu, B Dropulic, R Orentas, D Schneider - Molecular Therapy, 2016 - cell.com
In recent years, adoptive cell therapy using T cells engineered with chimeric antigen
receptors (CAR T) specific for CD19 has shown marked clinical efficacy. Nevertheless …
receptors (CAR T) specific for CD19 has shown marked clinical efficacy. Nevertheless …
232. High Levels of iCasp9 Expression Are Needed for Suicide Gene Transfer
Mesenchymal stem cells (MSC) are adult multipotent stem cells that possess regenerative
and immunomodulatory properties. They have been widely investigated as therapeutic …
and immunomodulatory properties. They have been widely investigated as therapeutic …
115 An NFAT promoter based fluorescent Jurkat cell platform for high-throughput screening of chimeric antigen receptor (CAR) constructs
Background CAR T-cells have exhibited efficacious treatment of hematological
malignancies, such as Acute Myeloid Leukemia (AML). Upon antigen binding, CARs initiate …
malignancies, such as Acute Myeloid Leukemia (AML). Upon antigen binding, CARs initiate …
Theranostic CAR T cell targeting: A brief review
More than hundred years ago, Paul Ehrlich postulated that our immune system should be
able to recognize tumor cells. Just recently, the development of check point inhibitors …
able to recognize tumor cells. Just recently, the development of check point inhibitors …
[HTML][HTML] Adapter chimeric antigen receptor (aCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting
S Grote, CM Seitz, S Diepold, M Buchner, C Baden… - Blood, 2018 - Elsevier
Chimeric antigen receptor (CAR) expressing T cells (CAR-Ts) have demonstrated
tremendous clinical success, especially when targeted against the B-phenotypic antigens …
tremendous clinical success, especially when targeted against the B-phenotypic antigens …
Activity of CAR19 T cells secreting impact fusion proteins against hematopoietic and solid tumors.
F Dufort, L Su, L Wu, A Birt, R Lobb, C Ambrose… - 2018 - ascopubs.org
e15046 Background: CAR T cells targeting CD19 (CAR19s) can eradicate B cell leukemias
and lymphomas. We have engineered CAR19s to secrete a wide variety of retargeting …
and lymphomas. We have engineered CAR19s to secrete a wide variety of retargeting …
[PDF][PDF] Effects of chimeric antigen receptor (CAR) expression on regulatory T cells
Recurrence of disease remains the largest cause of mortality for many patients transplanted
for relapsed or refractory B cell malignancies. Modification of primary T cells to express a …
for relapsed or refractory B cell malignancies. Modification of primary T cells to express a …
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography
Chimeric antigen receptor (CAR) T cell therapy for hematologic malignancies is fraught with
several unknowns, including number of functional T cells that engage target tumor, durability …
several unknowns, including number of functional T cells that engage target tumor, durability …
533. Targeting Intracellular Antigens Using Chimeric Antigen Receptors
MV Maus, T Merghoub, G Jakka, J Plotkin… - Molecular Therapy, 2012 - cell.com
T cells can be redirected to a desired antigen-specificity with one of two types of molecularly
designed antigen receptors, either based on native T cell receptors, or chimeric antigen …
designed antigen receptors, either based on native T cell receptors, or chimeric antigen …