Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous …
KK Yoder, C Wang, ED Morris - Journal of Nuclear Medicine, 2004 - Soc Nuclear Med
Change in binding potential (ΔBP) is often used to indicate alterations in neurotransmitter
concentration in response to stimuli. Increasingly, it is being used in bolus studies as a …
concentration in response to stimuli. Increasingly, it is being used in bolus studies as a …
[HTML][HTML] Limitations of SRTM, Logan graphical method, and equilibrium analysis for measuring transient dopamine release with [11C] raclopride PET
JM Sullivan, SJ Kim, KP Cosgrove… - American journal of …, 2013 - ncbi.nlm.nih.gov
Conventional PET methods to estimate [11 C] raclopride binding potential (BP ND) assume
that endogenous dopamine concentration does not change during the scan time. However …
that endogenous dopamine concentration does not change during the scan time. However …
Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands
To describe the effect of endogenous dopamine on [11C] raclopride binding, we previously
extended the conventional receptor ligand model to include dynamic changes in …
extended the conventional receptor ligand model to include dynamic changes in …
Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C] raclopride
Y Ikoma, H Watabe, T Hayashi, Y Miyake, N Teramoto… - Neuroimage, 2009 - Elsevier
Positron emission tomography (PET) with [11C] raclopride is widely used to investigate
temporal changes in the dopamine D2 receptor system attributed to the dopamine release …
temporal changes in the dopamine D2 receptor system attributed to the dopamine release …
A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies
The widely used Logan plot in radioligand receptor dynamic PET studies produces marked
noise-induced negative biases in the estimates of total distribution volume (DVT) and …
noise-induced negative biases in the estimates of total distribution volume (DVT) and …
Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy—a simulation study based on …
The D2 dopamine receptor density ranges from 0.2 to 40 nM among human brain regions.
For high density regions radioligands like [11C] raclopride provide accurate and reliable …
For high density regions radioligands like [11C] raclopride provide accurate and reliable …
Time‐course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge
DJ Scott, CS Stohler, RA Koeppe, JK Zubieta - Synapse, 2007 - Wiley Online Library
Abstract Positron Emission Tomography (PET) with appropriate radiotracers and
quantification methods allows the detection of changes in endogenous neurotransmission …
quantification methods allows the detection of changes in endogenous neurotransmission …
Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method
CC Constantinescu, KK Yoder… - Physics in Medicine …, 2008 - iopscience.iop.org
We previously developed a model-independent technique (non-parametric ntPET) for
extracting the transient changes in neurotransmitter concentration from paired (rest & …
extracting the transient changes in neurotransmitter concentration from paired (rest & …
Assessment of motion and model bias on the detection of dopamine response to behavioral challenge
Compartmental modeling analysis of 11C-raclopride (RAC) PET data can be used to
measure the dopaminergic response to intra-scan behavioral tasks. Bias in estimates of …
measure the dopaminergic response to intra-scan behavioral tasks. Bias in estimates of …
[PDF][PDF] Measurement of dopamine release with continuous infusion of [11C] raclopride: optimization and signal-to-noise considerations
H Watabe, CJ Endres, A Breier, B Schmall… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Accordingtothesimulationstudy, theoptimalscantimesforpre and poststimulusscans were
39— 50and 58— i® mm, respec tively. The optimal timing resulted in a 28% noise …
39— 50and 58— i® mm, respec tively. The optimal timing resulted in a 28% noise …
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