cGMP production of [18F] 3F4AP for human PET imaging
K Ramos-Torres, J Noel, D Vesper, P Rice… - 2021 - Soc Nuclear Med
1461 Objectives:[18 F] 3-fluoro-4-aminopyridine ([18 F] 3F4AP) is a PET radioligand for
imaging demyelinated lesions in the brain based on the multiple sclerosis (MS) drug 4 …
imaging demyelinated lesions in the brain based on the multiple sclerosis (MS) drug 4 …
Evaluation of anesthesia effects on the brain uptake and metabolism of demyelination tracer [18F] 3F4AP
2956 Introduction:[18 F] 3-fluoro-4-aminopyridine ([18 F] 3F4AP) is a PET radioligand for
imaging demyelinated lesions in the central nervous system (CNS) based on the multiple …
imaging demyelinated lesions in the central nervous system (CNS) based on the multiple …
Syntheses of [11C] 2-and [11C] 3-trifluoromethyl-4-aminopyridine: potential PET radioligands for imaging demyelinating diseases
619 Objectives: Trifluoromethyl groups are of great interest in radiopharmaceuticals as they
can enhance chemical and metabolic stability and allow for the manipulation of …
can enhance chemical and metabolic stability and allow for the manipulation of …
First-in-human brain imaging with [18F] 3F4AP, a PET tracer developed for imaging demyelination
N Guehl, Y Sun, A Russo, K Ramos-Torres… - 2022 - Soc Nuclear Med
2485 Introduction:[18 F] 3F4AP is a radiofluorinated derivative of the multiple sclerosis drug
4-aminopyridine.[18 F] 3F4AP binds to K+ channels of demyelinated axons and has shown …
4-aminopyridine.[18 F] 3F4AP binds to K+ channels of demyelinated axons and has shown …
Automated radiochemical synthesis of [18F] 3F4AP: a novel PET tracer for imaging demyelinating diseases
P Brugarolas, M Bhuiyan, A Kucharski… - JoVE (Journal of …, 2017 - jove.com
3-[18F] fluoro-4-aminopyridine,[18F] 3F4AP, is a radiofluorinated analog of the FDA-
approved drug for multiple sclerosis 4-aminopyridine (4AP). This compound is currently …
approved drug for multiple sclerosis 4-aminopyridine (4AP). This compound is currently …
Fluorinated 4-aminopyrdines as PET tracers for MS
493 Objectives Multiple sclerosis (MS) is a common neurological disease for which no PET
tracers are available. Tracers are in development for inflammation (TSPO ligands) and …
tracers are available. Tracers are in development for inflammation (TSPO ligands) and …
Development of a PET tracer for MS
1124 Objectives Multiple sclerosis (MS) is a common neurological disease for which no PET
tracers are available. Tracers are in development for brain inflammation (eg TSPO ligands) …
tracers are available. Tracers are in development for brain inflammation (eg TSPO ligands) …
[HTML][HTML] Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
P Brugarolas, MQ Wilks, J Noel, JA Kaiser… - European journal of …, 2023 - Springer
Abstract Purpose [18F] 3F4AP is a novel PET radiotracer that targets voltage-gated
potassium (K+) channels and has shown promise for imaging demyelinated lesions in …
potassium (K+) channels and has shown promise for imaging demyelinated lesions in …
Syntheses of [11 C] 2-and [11 C] 3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases
Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabelled 4-
aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases …
aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases …
First Experience with Clinical-Grade [18F]FPP(RGD)2: An Automated Multi-step Radiosynthesis for Clinical PET Studies
FT Chin, B Shen, S Liu, RA Berganos, E Chang… - Molecular Imaging and …, 2012 - Springer
Purpose A reliable and routine process to introduce a new 18 F-labeled dimeric RGD-
peptide tracer ([18 F] FPP (RGD) 2) for noninvasive imaging of α v β 3 expression in tumors …
peptide tracer ([18 F] FPP (RGD) 2) for noninvasive imaging of α v β 3 expression in tumors …