18F-labeled (2 S, 4 R)-4-fluoro-l-glutamine (4F-GLN) has demonstrated high uptake in tumor
cells that undergo high growth and proliferation. Similar tumor targeting properties have also …

Glucose and glutamine are the most abundant nutrients for producing energy and building
blocks in normal and tumor cells. Increased glycolysis in tumors, the Warburg Effect, is the …

Although the growth and proliferation of most tumors is fueled by glucose, some tumors are
more likely to metabolize glutamine. In particular, tumor cells with the upregulated c-Myc …

We have previously reported that N-(2-[18F] fluoropropionyl)-l-methionine ([18F] FPMET)
selectively accumulates in tumors. However, due to the poor pharmacokinetics of [18F] …

18F-(2S, 4R)-4-fluoroglutamine (18F-FGln) is an investigational PET radiotracer for imaging
tumor glutamine flux and metabolism. The aim of this study was to investigate its …

Changes in gene expression, metabolism, and energy requirements are hallmarks of cancer
growth and self-sufficiency. Upregulation of the PI3K/Akt/mTor pathway in tumor cells has …

Sustaining the growth of tumor cells requires extra energy and metabolic building blocks. In
addition to consuming glucose, glutamine may play the role as an alternative source of …

Recently, there has been a renewed interest in the study of tumor metabolism above and
beyond the Warburg effect. Studies on cancer cell metabolism have provided evidence that …

The PET radiotracer 18F-(2 S, 4 R) 4-fluoroglutamine (18F-Gln) reflects glutamine transport
and can be used to infer glutamine metabolism. Mouse xenograft studies have …

Introduction The emerging evidence that demonstrated the extra-demand of glutamine for
cancer surviving strongly called for the development of PET tracer for imaging glutamine …