An in vivo comparison of two estrogen-receptor-binding radiopharmaceuticals of high
specific activity, 16 alpha-[77Br] bromoestradiol-17 beta and 16 alpha-[125I] iodoestradiol …

16 alpha [77Br] Bromo-11 beta-methoxyestradiol-17 beta [MBE (Br-77)], a compound with
high affinity for the estrogen receptor and with low nonspecific binding, has been prepared …

Abstract 16α-[77 Br]-Bromoestradiol-17β (3a) has been synthesized from estrone enol
diacetate (1) by bromination with Na 77 Br and hydrogen peroxide-acetic acid, followed by …

We have synthesized an analog of 16 α-iodoestradiol, 1l β-methoxy-16 α-iodo-estra-1, 3, 5-
(10) triene-3, 17 β-diol (16 α-iodo-ll β-methoxyestradiol), as a potential radiopharmaceutical …

Estrogen Receptor Binding Radiopharmaceuticals: II. Tissue Distribution of 17a-Methy (estradici
in Normal and Tumor-Bearing Rats Page 1 Estrogen Receptor Binding …

MATERIALS AND METHODS Animals. Unlessstatedotherwise, we usedFischer femalerats (I
50— 250g) bearingtransplantedmammary adenocarcinomaI3, 762.* Sprague-Dawleyrats …

MATERIALS AND METhODS 1l/1-Methoxy-l6fi-bromo-l713-estradiol was synthesized as
previously described (21). Na'23I, produced by the tellurium 124 (†24TeXp, 2n) nuclear …

Abstract [77 Br] 17-α-Bromoethynylestradiol has been prepared by direct, no-carrier-added
bromination of 17-α-iodoethynylestradiol. The product thus obtained has an effective specific …

RESULTS In vivodistributionstudies in mature female rats. The in vivo characteristics of
tritiated ethynylestradiol and moxestrol were first investigated in normal female rats at …

A series of three 125 I-labeled 17α-iodovinylestradiol derivatives previously demonstrated to
have a selectivity for estrogen receptor tissues in immature female rats were selected for …