Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates
KA Kurdziel, DO Kiesewetter, RE Carson… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Multidrug resistance (MDR) associated with increased expression and function of the P-
glycoprotein (Pgp) efflux pump often causes chemotherapeutic failure in cancer. To provide …
glycoprotein (Pgp) efflux pump often causes chemotherapeutic failure in cancer. To provide …
Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors …
V Sharma, JL Prior, MG Belinsky, GD Kruh… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Overexpression of multidrug resistance (MDR1) P-glycoprotein (Pgp) remains an important
barrier to successful chemotherapy in cancer patients and impacts the pharmacokinetics of …
barrier to successful chemotherapy in cancer patients and impacts the pharmacokinetics of …
[PDF][PDF] Evaluation of 11C-colchicine for PET imaging of multiple drug resistance
A Levchenko, BM Mehta, JB Lee… - Journal of Nuclear …, 2000 - Soc Nuclear Med
OverexpressionofP-glycoprotein (P-gp) canconfermultipledrug resistance (MDR) phenotype
on cancer cells and tumors by reducing intracellularaccumulationof various cytotoxic agents …
on cancer cells and tumors by reducing intracellularaccumulationof various cytotoxic agents …
Imaging multidrug resistance with 4-[18F] fluoropaclitaxel
KA Kurdziel, JD Kalen, JI Hirsch, JD Wilson… - Nuclear medicine and …, 2007 - Elsevier
Multidrug resistance (MDR) is a cause of treatment failure in many cancer patients. MDR
refers to a phenotype whereby a tumor is resistant to a large number of natural …
refers to a phenotype whereby a tumor is resistant to a large number of natural …
Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity
V Sharma - Bioconjugate chemistry, 2004 - ACS Publications
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is
one of the best characterized transporter-mediated barriers to successful chemotherapy in …
one of the best characterized transporter-mediated barriers to successful chemotherapy in …
Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-sestamibi
HM Bigott, JL Prior, DR Piwnica-Worms… - Molecular …, 2005 - journals.sagepub.com
The best characterized mechanism of multidrug resistance (MDR) in cancer involves the
MDR1 efflux transporter P-glycoprotein (Pgp). The positron-emitting radiotracer hexakis (2 …
MDR1 efflux transporter P-glycoprotein (Pgp). The positron-emitting radiotracer hexakis (2 …
Clinical imaging of multidrug resistance in cancer
S Del Vecchio, A Ciarmiello… - The Quarterly Journal of …, 1999 - search.proquest.com
The most well-characterized mechanism of multidrug resistance (MDR) involves P-
glycoprotein (Pgp), a transmembrane protein acting as an ATP-dependent drug efflux pump …
glycoprotein (Pgp), a transmembrane protein acting as an ATP-dependent drug efflux pump …
Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with 18F-fluoropaclitaxel
A Gangloff, WA Hsueh, AL Kesner… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Paclitaxel (PAC) is widely used as a chemotherapy drug in the treatment of various
malignancies, including breast, ovarian, and lung cancers. We examined the biodistribution …
malignancies, including breast, ovarian, and lung cancers. We examined the biodistribution …
[PDF][PDF] Technetium-99m-furifosmin as an agent for functional imaging of multidrug resistance in tumors
JR Ballinger, T Muzzammil… - Journal of Nuclear …, 1997 - Soc Nuclear Med
P-glycoprotein, the membrane transporter that is a mechanism of multidrug resistance
(MDR) in tumors. This has been further inves tigated in the rat mammary carcinoma cell line …
(MDR) in tumors. This has been further inves tigated in the rat mammary carcinoma cell line …
Visualization of multidrug resistance in vivo
NH Hendrikse, EJF Franssen… - European journal of …, 1999 - Springer
Various mechanisms are involved in multidrug resistance (MDR) for chemotherapeutic
drugs, such as the drug efflux pumps, P-glycoprotein (Pgp) and multidrug resistance …
drugs, such as the drug efflux pumps, P-glycoprotein (Pgp) and multidrug resistance …