[PDF][PDF] In vitro and in vivo characterization of 4-[125I] iododexetimide binding to muscarinic cholinergic receptors in the rat heart
K Matsumura, Y Uno, U Scheffel… - Journal of Nuclear …, 1991 - Soc Nuclear Med
MATERIALSAND METHODS Iodine-125-labeled 4-iododexetimide (4-['251] iododexetim
ide) and 4-iodolevetimide (4-['25I] iodolevetimide) were syn 4-[1251] iododexetimidebinding …
ide) and 4-iodolevetimide (4-['25I] iodolevetimide) were syn 4-[1251] iododexetimidebinding …
Effects of atropine treatment on in vitro and in vivo binding of 4-[125I]-dexetimide to central and myocardial muscarinic receptors
Y Uno, K Matsumura, U Scheffel, AA Wilson… - European journal of …, 1991 - Springer
Upregulation of muscarinic cholinergic receptors (mAChR) after chronic atropine treatment
has been described previously. The present study was designed to evaluate 4-iodine-125 …
has been described previously. The present study was designed to evaluate 4-iodine-125 …
Radiosynthesis of [123I] N-methyl-4-iododexetimide and [123I] N-methyl-4-iodolevetimide: in vitro and in vivo characterisation of binding to muscarinic receptors in the …
[123I] N-methyl-4-iododexetimide,[123I] MIDEX, and its pharmacologically inactive
enantiomer [123I] N-methyl-4-iodolevetimide,[123I] MILEV were prepared via electrophilic …
enantiomer [123I] N-methyl-4-iodolevetimide,[123I] MILEV were prepared via electrophilic …
Synthesis and biological evaluation of iodine-125-and iodine-123-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist
AA Wilson, RF Dannals, HT Ravert… - Journal of medicinal …, 1989 - ACS Publications
A series of halogenated racemic analogues of dexetimide (1) was synthesized and their
affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide …
affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide …
Influence of acetylcholine on binding of 4-[125I] iododexetimide to muscarinic brain receptors
M Weckesser, A Fixmann, M Holschbach… - Nuclear medicine and …, 1998 - Elsevier
The distribution of nicotinic and muscarinic cholinergic receptors in the human brain in vivo
has been successfully characterized using radiolabeled tracers and emission tomography …
has been successfully characterized using radiolabeled tracers and emission tomography …
11C-methiodide quinuclidinyl benzilate a muscarinic antagonist for in vivo studies of myocardial muscarinic receptors
M Maziere, G Berger, JM Godot, C Prenant… - Journal of …, 1983 - Springer
A method for labeling MQNB (Methiodide quinuclidinyl benzilate) with carbon-11 using 11 C-
methyl iodide is reported. Injectable labeled product (100 mCi; max. 200 mCi) …
methyl iodide is reported. Injectable labeled product (100 mCi; max. 200 mCi) …
Iodine-123N- methyl-4-iododexetimide: a new radioligand for single-photon emission tomographic imaging of myocardial muscarinic receptors
Cardiac muscarinic receptor ligands suitable for positron emission tomography have
previously been characterised. Attempts to develop radioligands of these receptors suitable …
previously been characterised. Attempts to develop radioligands of these receptors suitable …
Visualization of muscarinic acetylcholine receptors in the human heart using 11C-methyl-QNB and positron emission tomography
A Syrota, M Maziere, M Crouzel, J Sastre… - Nuclear medicine and …, 1982 - inis.iaea.org
[en] It has been recently demonstrated that it was possible to characterize in vivo
myocardium muscarinic receptors by injecting baboons with the antagonist …
myocardium muscarinic receptors by injecting baboons with the antagonist …
In vivo visualization of central muscarinic receptors using [11C] quinuclidinyl benzilate and positron emission tomography in baboons
M Varastet, E Brouillet, C Chavoix, C Prenant… - European journal of …, 1992 - Elsevier
The muscarinic antagonist, quinuclidinyl benzilate (QNB), labeled with carbon 11 was used
as a radioligand to visualize in vivo by positron emission tomography (PET) the central …
as a radioligand to visualize in vivo by positron emission tomography (PET) the central …
Imaging muscarinic cholinergic receptors using I-123-paraiododexetimide and emission computed tomography
JJ Frost, AA Wilson, RF Dannals, HT Ravert… - J. Nucl. Med.;(United …, 1985 - osti.gov
Dexetimide is a high affinity muscarinic cholinergic receptor (MR) antagonist which binds
preferentially to MR in vivo. The corresponding optical isomer of dexetimide is levetimide …
preferentially to MR in vivo. The corresponding optical isomer of dexetimide is levetimide …