PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer

K Zhang, MR Aruva, N Shanthly, CA Cardi… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Among US men, prostate cancer (PC) accounts for 29% of all newly diagnosed cancers. A
reliable scintigraphic agent to image PC and its metastatic or recurrent lesions and to …

VPAC1 targeted 64Cu-TP3805 positron emission tomography imaging of prostate cancer: Preliminary evaluation in man

S Tripathi, EJ Trabulsi, L Gomella, S Kim, P McCue… - Urology, 2016 - Elsevier
Objective To evaluate 64 Cu-TP3805 as a novel biomolecule, to positron emission
tomography (PET) image prostate cancer (PC), at the onset of which VPAC1, the superfamily …

PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog

ML Thakur, MR Aruva, J Gariepy, P Acton… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The purpose of this study was to assess the feasibility of PET imaging of oncogene VPAC1
receptors overexpressed in human breast cancer cells. Methods: Vasoactive intestinal …

VPAC1 receptors for imaging breast cancer: a feasibility study

ML Thakur, K Zhang, A Berger… - Journal of Nuclear …, 2013 - Soc Nuclear Med
VPAC1 encodes G-protein–coupled receptors expressed on all breast cancer (BC) cells at
the onset of the disease, but not on benign lesions. Our extensive preclinical studies have …

Expression of functional PACAP/VIP receptors in human prostate cancer and healthy tissue

MO Garcı́a-Fernández, RM Solano, MJ Carmena… - Peptides, 2003 - Elsevier
Vasoactive intestinal peptide (VIP) is involved in prostate cell proliferation and function. VIP
and pituitary adenylate cyclase-activating peptide (PACAP) are similarly recognized by …

PACAP and type I PACAP receptors in human prostate cancer tissue

C Moretti, C Mammi, GV Frajese… - Annals of the New …, 2006 - Wiley Online Library
We characterized the expression and localization of pituitary adenylate cyclase‐activating
polypeptide (PACAP) and its specific type I receptor variants in prostatic, hyperplastic, and …

Development of a voided urine assay for detecting prostate cancer non‐invasively: a pilot study

EJ Trabulsi, SK Tripathi, L Gomella… - BJU …, 2017 - Wiley Online Library
Objective To validate a hypothesis that prostate cancer can be detected non‐invasively by a
simple and reliable assay by targeting genomic VPAC receptors expressed on malignant …

In Vitro Evaluation of VIP/PACAP Receptors in Healthy and Diseased Human Tissues: Clinical Implications

JC Reubi - Annals of the New York Academy of Sciences, 2000 - Wiley Online Library
The evaluation of peptide receptors in man is relevant to identifying the physiological target
tissues of a given peptide and to selecting diseases with a sufficient receptor overexpression …

64CuCl2 PET/CT in prostate cancer relapse

A Piccardo, F Paparo, M Puntoni, S Righi… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Our objective was to evaluate the biodistribution, kinetics, and radiation dosimetry of
64CuCl2 in humans and to assess the ability of 64CuCl2 PET/CT to detect prostate cancer …

Immunocytochemical Identification of VPAC1, VPAC2, and PAC1 Receptors in Normal and Neoplastic Human Tissues with Subtype-Specific Antibodies

S Schulz, C Röcken, C Mawrin, W Weise… - Clinical Cancer …, 2004 - AACR
Human tumors frequently overexpress receptors for vasoactive intestinal peptide (VIP) and
pituitary adenylate cyclase-activating peptide (PACAP). However, none of the VIP/PACAP …