2-year natural decline of cardiac sympathetic innervation in idiopathic Parkinson disease studied with 11C-hydroxyephedrine PET

KK Wong, DM Raffel, NI Bohnen, G Altinok… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The objective of this study was to detect regional patterns of cardiac sympathetic
denervation in idiopathic Parkinson disease (IPD) using 11C-hydroxyephedrine (11C-HED) …

Pattern of Cardiac Sympathetic Denervation in Idiopathic Parkinson Disease Studied with 11C Hydroxyephedrine PET

KK Wong, DM Raffel, RA Koeppe, KA Frey, NI Bohnen… - Radiology, 2012 - pubs.rsna.org
Purpose To determine whether cardiac sympathetic denervation in idiopathic Parkinson
disease (IPD) affects the left ventricle in a distinct regional pattern versus a more global …

Reliable quantification of myocardial sympathetic innervation and regional denervation using [11C]meta-hydroxyephedrine PET

KY Wu, JGE Zelt, T Wang, V Dinculescu… - European Journal of …, 2020 - Springer
Purpose Cardiac sympathetic nervous system (SNS) dysfunction is associated with poor
prognosis in chronic heart failure patients. This study characterized the reproducibility and …

PET measurement of cardiac and nigrostriatal denervation in Parkinsonian syndromes

DM Raffel, RA Koeppe, R Little, CN Wang… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Scintigraphic imaging with 123I-metaiodobenzylguanidine (123I-MIBG) has demonstrated
extensive losses of cardiac sympathetic neurons in idiopathic Parkinson's disease (IPD). In …

[N-methyl 11C]meta-Hydroxyephedrine positron emission tomography in Parkinson's disease and multiple system atrophy

G Berding, CH Schrader, T Peschel… - European journal of …, 2003 - Springer
Orthostatic hypotension (OH) can be present in idiopathic Parkinson's disease (IPD) as well
as in atypical parkinsonian syndromes such as multiple system atrophy (MSA). According to …

Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure

DN Tipre, DS Goldstein - Journal of Nuclear Medicine, 2005 - Soc Nuclear Med
The uptake of 6-18F-fluorodopamine by cardiac noradrenergic nerves enables visualization
of the sympathetic innervation of the left ventricular myocardium by PET. Patients with …

Cardiac sympathetic denervation is not related to nigrostriatal degeneration in Parkinson's disease

A Chiaravalloti, A Stefani, D Di Biagio… - Annals of nuclear …, 2013 - Springer
Aim The aim of our study was to investigate the relationship between myocardial
sympathetic degeneration and nigrostriatal impairment in patients affected by Parkinson's …

Reproducible quantification of regional sympathetic denervation with [11C] meta-hydroxyephedrine PET imaging

JZ Wang, JB Moody, N Kaps, D Britt, A Lavallee… - Journal of Nuclear …, 2021 - Elsevier
Background Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest
in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between …

Assessment of myocardial sympathetic innervation with 18F-FDOPA-PET/CT in patients with autonomic dysfunction: feasibility study in IPD patients

H Goyal, A Sharma, C Patel, KK Deepak… - Journal of Nuclear …, 2022 - Elsevier
Background Dysfunction and denervation of myocardial nor-adrenergic sympathetic
neurons has been documented in IPD patients with dysautonomia. The aim of this study was …

Progressive loss of cardiac sympathetic innervation in Parkinson's disease

ST Li, R Dendi, C Holmes, DS Goldstein - Annals of neurology, 2002 - Wiley Online Library
This study addressed whether cardiac sympathetic denervation progresses over time in
Parkinson's disease. In 9 patients without orthostatic hypotension, 6‐[18F] fluorodopamine …