Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats

JEM van Eerd, E Vegt, JFM Wetzels… - Journal of nuclear …, 2006 - Soc Nuclear Med
111In-Diethylenetriaminepentaacetic acid-octreotide generally is used for the scintigraphic
imaging of neuroendocrine and other somatostatin receptor–positive tumors. On the basis of …

Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin

E Vegt, JFM Wetzels, FGM Russel… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Peptide receptor–mediated radiotherapy of neuroendocrine and other somatostatin receptor–
positive tumors with radiolabeled somatostatin analogs has been applied in several …

Identification of the Soluble in Vivo Metabolites of Indium-111-Diethylenetriaminepentaacetic Acid-d-Phe1-Octreotide

LA Bass, MV Lanahan, JR Duncan, JL Erion… - Bioconjugate …, 1998 - ACS Publications
Indium-111-diethylenetriaminepentaacetic Acid-d-phenylalanine1-octreotide (111In-DTPA-
octreotide) is a cyclic eight amino acid somatostatin analogue which is approved for gamma …

Reducing renal uptake of radiolabeled peptides using albumin fragments

E Vegt, JEM van Eerd, A Eek, WJG Oyen… - Journal of Nuclear …, 2008 - Soc Nuclear Med
In most types of peptide receptor radionuclide therapy, the maximum activity dose that can
be administered is limited by high and persistent renal retention of the radiolabeled …

Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine

EJ Rolleman, R Valkema, M De Jong, PP Kooij… - European journal of …, 2003 - Springer
As scintigraphy with [111 In-DTPA 0] octreotide has become a standard technique in
analysing somatostatin receptor-receptor positive lesions such as neuroendocrine tumours …

Uptake of [111In-DTPA0] octreotide in the rat kidney is inhibited by colchicine and not by fructose

EJ Rolleman, EP Krenning… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The high renal uptake of radiolabeled somatostatin analogs is dose limiting. Lowering this
uptake permits higher radioactivity doses and, thus, tumor doses to be administered. We …

Tumor response after [90Y-DOTA0, Tyr3] octreotide radionuclide therapy in a transplantable rat tumor model is dependent on tumor size

M de Jong, WAP Breeman, BF Bernard… - Journal of Nuclear …, 2001 - Soc Nuclear Med
A promising application of radiolabeled somatostatin analogs is peptide receptor–targeted
radionuclide therapy of somatostatin receptor–expressing tumors. A suitable radionuclide is …

[HTML][HTML] Dose-response effect of Gelofusine on renal uptake and retention of radiolabelled octreotate in rats with CA20948 tumours

M Melis, M Bijster, M de Visser… - European journal of …, 2009 - Springer
Purpose Peptide receptor radionuclide therapy using β-emitting radiolabelled somatostatin
analogues like DOTA, Tyr 3-octreotate shows beneficial results in patients suffering from …

Tumour uptake of the radiolabelled somatostatin analogue [DOTA0,TYR3]octreotide is dependent on the peptide amount

M de Jong, WAP Breeman, BF Bernard… - European journal of …, 1999 - Springer
Radiolabelled tumour receptor-binding peptides can be used for in vivo scintigraphic
imaging. Recently, the somatostatin analogue [Tyr 3] octreotide (d-Phe-c (Cys-Tyr-d-Trp-Lys …

Practical dosimetry of peptide receptor radionuclide therapy with 90Y-labeled somatostatin analogs

S Pauwels, R Barone, S Walrand… - Journal of nuclear …, 2005 - Soc Nuclear Med
The challenge for internal therapy is to deliver the highest possible dose to the tumor while
sparing normal organs from damage. Currently, the potential risk of kidney and red marrow …