18F-PBR111 PET imaging in healthy controls and schizophrenia: Test–retest reproducibility and quantification of neuroinflammation
J Ottoy, L De Picker, J Verhaeghe… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Activated microglia express the translocator protein (TSPO) on the outer mitochondrial
membrane. 18F-PBR111 is a second-generation PET ligand that specifically binds the …
membrane. 18F-PBR111 is a second-generation PET ligand that specifically binds the …
[HTML][HTML] Perspective: solving the heterogeneity conundrum of TSPO PET imaging in psychosis
L De Picker, M Morrens - Frontiers in Psychiatry, 2020 - frontiersin.org
Positron emission tomography using ligands targeting translocator protein 18 kDa (TSPO
PET) is an innovative method to visualize and quantify glial inflammatory responses in the …
PET) is an innovative method to visualize and quantify glial inflammatory responses in the …
Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA
Objective: Neuroinflammation and abnormal immune responses are increasingly implicated
in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) …
in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) …
State-associated changes in longitudinal [18F]-PBR111 TSPO PET imaging of psychosis patients: evidence for the accelerated ageing hypothesis?
Objective To determine whether state-associated changes in microglial activity, measured
with translocator-protein positron emission tomography (TSPO PET), can be identified in …
with translocator-protein positron emission tomography (TSPO PET), can be identified in …
Imaging Neuroinflammation in Gray and White Matter in Schizophrenia: An In-Vivo PET Study With [ 18 F]-FEPPA
Neuroinflammation and abnormal immune responses have been implicated in
schizophrenia (SCZ). Past studies using positron emission tomography (PET) that examined …
schizophrenia (SCZ). Past studies using positron emission tomography (PET) that examined …
Meta-analysis of the glial marker TSPO in psychosis revisited: reconciling inconclusive findings of patient–control differences
P Plavén-Sigray, GJ Matheson… - Biological …, 2021 - biologicalpsychiatryjournal.com
Drugs targeting the immune system are a promising new approach for treatment of
schizophrenia. In search of methods for patient stratification, great effort has been invested …
schizophrenia. In search of methods for patient stratification, great effort has been invested …
Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?
MAM Sneeboer, T van der Doef, M Litjens… - Schizophrenia …, 2020 - Elsevier
Positron emission tomography (PET) with translocator 18 kDa protein (TSPO) radioligands
has frequently been used to investigate microglial activation in schizophrenia in vivo …
has frequently been used to investigate microglial activation in schizophrenia in vivo …
[HTML][HTML] In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C] DPA-713 PET and analysis of CSF and plasma
Several lines of evidence suggest aberrant immune response in schizophrenia, including
elevated levels of cytokines. These cytokines are thought to be produced by activated …
elevated levels of cytokines. These cytokines are thought to be produced by activated …
[HTML][HTML] In vivo (R)-[11C] PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
TF Van Der Doef, LD De Witte, AL Sutterland… - NPJ …, 2016 - nature.com
Evidence is accumulating that immune dysfunction is involved in the pathophysiology of
schizophrenia. It has been hypothesized that microglia activation is present in patients with …
schizophrenia. It has been hypothesized that microglia activation is present in patients with …
Neuroinflammation in schizophrenia-related psychosis: a PET study
J Doorduin, EFJ de Vries, ATM Willemsen… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Schizophrenia is a chronic and disabling brain disease characterized by psychotic episodes
with unknown etiology. It is suggested that neuroinflammation plays a role in the …
with unknown etiology. It is suggested that neuroinflammation plays a role in the …
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