MATERIALS AND METHODS MonoclonalAntibodyB72. 3 Mouse MAb B72. 3 is reactive with
a membrane glycopro tein of> l0@ daltons present in common human epithelial …

Lany studies have used radiolabeled anti-tumor antibodies (1-18) in efforts to improve the
staging of tumors and the detection of recurrent disease. The initial work used polyclonal …

The metabolism of radiolabeled antibodies is important for radioimmunoimaging and
therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and …

Using a bifunctional chelating agent, indium-111 was attached to a monoclonal antibody 10-
3D2, specific for a 126-kilodalton phosphoglycoprotein antigen asso ciated with human …

Newark, New Jersey colonic tumor xenograft, GW-39 (22), that is serially propa gated in
nude mice. Two weeks later, when the tumor size was 0.15 — 0.25 g, the animals (n= 5 for …

The biodistnbutionof yttrium-and indium-labeledmonoclonalantibody (MAb) B72. 3IgGusing
three differentchelateconjugates (SCN-Bz-EDTA, CA-DTPA, and SCN-Bz-DTPA) was …

As part of an open‐labeled nonrandomized multi‐institutional Phase III study, the authors
compared the results of In‐111 (In‐111) B72. 3 glycyl‐tyrosyl‐n‐diethylenetri …

MATERIALS AND METhODS Monoclonal Antibodies B72. 3, is a IgG, murine monoclonal
antibody, that recog nizes a high molecularweight (> 106D) colon cancer associ ated …

Pharmacokineticsof an Indium-111- LabeledMonoclonalAntibodyin CancerPatients Page 1
CLINICAL SCIENCES DJ Hnatowich, TW Griffin, C. Kosciuczyk, M. Rusckowski, RL Childs, JA …

Monoclonal antibodies (MAb) and their F (ab') 2 fragments to human colorectal carcinoma
(CRC) and human melanoma-associated antigens were conjugated to …