Structural requirements for in vivo detection of cell death with 99mTc-annexin V
JF Tait, C Smith, FG Blankenberg - Journal of Nuclear Medicine, 2005 - Soc Nuclear Med
99mTc-Annexin V is used to image cell death in vivo via high-affinity binding to exposed
phosphatidylserine. We investigated how changes in membrane-binding affinity, molecular …
phosphatidylserine. We investigated how changes in membrane-binding affinity, molecular …
Improved detection of cell death in vivo with annexin V radiolabeled by site-specific methods
JF Tait, C Smith, Z Levashova, B Patel… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Labeled annexin V is widely used to detect cell death in vitro and in vivo. Nearly all studies
have been done with annexin V derivatized via amine-directed bifunctional agents; it was …
have been done with annexin V derivatized via amine-directed bifunctional agents; it was …
Development and Characterization of Annexin V Mutants with Endogenous Chelation Sites for 99mTc
JF Tait, DS Brown, DF Gibson… - Bioconjugate …, 2000 - ACS Publications
[99mTc] Annexin V can be used to image organs undergoing cell death during cancer
chemotherapy and organ transplant rejection. To simplify the preparation and labeling of …
chemotherapy and organ transplant rejection. To simplify the preparation and labeling of …
99mTc-labeled annexin V fragments: a potential SPECT radiopharmaceutical for imaging cell death
A Mukherjee, K Kothari, G Tóth, E Szemenyei… - Nuclear medicine and …, 2006 - Elsevier
INTRODUCTION: Annexin V is a protein that binds to phosphatidylserine exposed on dying
cells. The phosphatidylserine-specific sequence is attributed to a chain on the N-terminal of …
cells. The phosphatidylserine-specific sequence is attributed to a chain on the N-terminal of …
Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis
K Ohtsuki, K Akashi, Y Aoka, FG Blankenberg… - European journal of …, 1999 - Springer
Either inadequate or excessive apoptosis (programmed cell death) is associated with many
diseases. A method to image apoptosis in vivo, rather than requiring histologic evaluation of …
diseases. A method to image apoptosis in vivo, rather than requiring histologic evaluation of …
[PDF][PDF] Imaging of apoptosis (programmed cell death) with 99mTc annexin V
FG Blankenberg, PD Katsikis, JF Tait… - Journal of Nuclear …, 1999 - Soc Nuclear Med
Results: Membrane-bound radiolabeled annexin V activity lin early correlated to total
fluorescence as observed by FITC annexin V flow cytometry in Jurkat T-cell cultures induced …
fluorescence as observed by FITC annexin V flow cytometry in Jurkat T-cell cultures induced …
Patient dosimetry of intravenously administered 99mTc-annexin V
GJ Kemerink, H Liem, L Hofstra… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Annexin V labeled with 99mTc is evaluated as a potential in vivo marker for tissue with
increased apoptosis. Promising results in patients have been obtained with 99mTc-(n-1 …
increased apoptosis. Promising results in patients have been obtained with 99mTc-(n-1 …
Development of annexin V mutants suitable for labeling with Tc (I)-carbonyl complex
JF Tait, C Smith, DF Gibson - Bioconjugate chemistry, 2002 - ACS Publications
99mTc-annexin V can be used to image organs undergoing cell death during cancer
chemotherapy and organ transplant rejection. We investigated whether the novel Tc …
chemotherapy and organ transplant rejection. We investigated whether the novel Tc …
Functional comparison of annexin V analogues labeled indirectly and directly with iodine-124
B Dekker, H Keen, D Shaw, L Disley, D Hastings… - Nuclear medicine and …, 2005 - Elsevier
We are interested in imaging cell death in vivo using annexin V radiolabeled with 124I. In
this study,[124I] 4IB-annexin V and [124I] 4IB-ovalbumin were made using [124I] N …
this study,[124I] 4IB-annexin V and [124I] 4IB-ovalbumin were made using [124I] N …
Preparation, in vitro and in vivo evaluation of 99mTc-Annexin B1: A novel radioligand for apoptosis imaging
Q Luo, Z Zhang, F Wang, H Lu, Y Guo, R Zhu - … and biophysical research …, 2005 - Elsevier
To develop a radiopharmaceutical for apoptosis imaging, Annexin B1, a new Ca2+-
dependent phosphatidylserine (PS)-binding protein, was directly radiolabeled with 99mTc …
dependent phosphatidylserine (PS)-binding protein, was directly radiolabeled with 99mTc …