68Ga-aquibeprin and 68Ga-avebetrin are tracers for selective in vivo mapping of integrins
α5β1 and αvβ3, respectively, by PET. Because both tracers exhibit high affinity to their …

Despite in vivo mapping of integrin αvβ3 expression being thoroughly investigated in recent
years, its clinical value is still not well defined. For imaging of angiogenesis, the integrin …

Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to
malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually …

Purpose To develop a new probe for the αvβ6-integrin and assess its potential for PET
imaging of carcinomas. Methods Ga-68-Trivehexin was synthesized by trimerization of the …

A rapid one-step 18F labeling reaction with fluoridealuminum complex, which is based on
chelation chemistry, has received a surge of interest for 18F radiolabeling of peptides. In this …

Aim: To visualize neovasculature and/or tumour integrin α v β 3 we selected the binding
moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68 Ga …

Peptides containing the Arg-Gly-Asp (RGD) sequence have high affinity for αvβ3 integrin
receptors overexpressed in tumor cells. The objective of this research was to determine the …

Purpose Integrins are transmembrane receptors responsible for cell–cell adhesion and cell–
extracellular matrix binding and play an important role in angiogenesis and tumour …

The αv-integrins, cell adhesion molecules that are highly expressed on activated endothelial
cells and tumor cells but not on dormant endothelial cells or normal cells, present an …

The aim of this study was the evaluation of 68Ga‐DOTA‐E‐[c (RGDfK)] 2 as a novel PET
tracer to image αvβ3 and αvβ5 integrins. For this purpose, DOTA‐E‐[c (RGDfK)] 2 was …