The Area of Fibroblast Activation Exceeds the Hypoperfused Infarct Region in Patients with Acute Myocardial Infarction

J Diekmann, T Koenig, C Zwadlo, T Derlin, J Neuser… - 2021 - Soc Nuclear Med
135 Introduction: Radiolabelled inhibitors of fibroblast activation protein (FAPI) have been
introduced for PET imaging and may identify an early pathway leading to cardiac fibrosis …

Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with MR tissue characterization and subsequent functional outcome

J Diekmann, T Koenig, JT Thackeray… - Journal of Nuclear …, 2022 - Soc Nuclear Med
After acute myocardial infarction (AMI), fibroblast activation protein (FAP) upregulation
exceeds the infarct region. We sought further insights into the physiologic relevance by …

Predicting Remodeling and Outcome from Molecular Imaging of Fibroblast Activation in Patients after Acute Myocardial Infarction

J Diekmann, T Koenig, J Thackeray, T Derlin… - 2022 - Soc Nuclear Med
2217 Introduction: Molecular PET-imaging of fibroblast activation protein (FAP) has recently
been evaluated in patients after acute myocardial infarction (AMI). Here, the extent of FAP …

Visualization of fibroblast activation after myocardial infarction using 68Ga-FAPI-PET

J Kupusovic, L Kessler, J Ferdinandus… - European Heart …, 2021 - academic.oup.com
Introduction Fibroblast activation protein (FAP) alpha specifically expressed by activated
fibroblasts has been shown to be significantly involved in processes of tissue healing after …

Visualization of fibroblast activation after myocardial infarction using 68Ga-FAPI PET

L Kessler, J Kupusovic, J Ferdinandus… - Clinical Nuclear …, 2021 - journals.lww.com
Aims The aim of this retrospective analysis was to examine the pattern of cardiac 68 Ga-
fibroblast-activation protein-α inhibitor (FAPI) uptake in patients after acute myocardial …

Cardiac Fibroblast Activation in Patients After Acute Myocardial Infarction: Integration with Magnetic Resonance Tissue Characterization and Functional Outcome

J Diekmann, T König, JT Thackeray… - Nuklearmedizin …, 2022 - thieme-connect.com
Ziel/Aim After acute myocardial infarction (AMI), the area of fibroblast activation protein (FAP)
upregulation exceeds the infarct region. We sought to obtain further insights by correlating …

Molecular imaging of fibroblast activity after myocardial infarction using a 68Ga-labeled fibroblast activation protein inhibitor, FAPI-04

Z Varasteh, S Mohanta, S Robu… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Heart failure remains a major source of late morbidity and mortality after myocardial
infarction (MI). The temporospatial presence of activated fibroblasts in the injured …

Molecular imaging of fibroblast activity after acute myocardial infarct using 99mTc-iFAP: Comparison with cardiac magnetic resonance, myocardial perfusion imaging …

JEV Ahumada, EA Rosas, I Carvajal, GM Ramirez… - 2023 - Soc Nuclear Med
P479 Introduction: Cardiac remodeling is a major factor in the prognosis of patients that
undergo an acute myocardial infarction (AMI). Activation of fibroblast is mandatory for repair …

[HTML][HTML] Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction

J Diekmann, T Koenig, C Zwadlo, T Derlin… - Journal of the American …, 2021 - jacc.org
(A) Case example where fibroblast activation extensively exceeds the infarct region.(B)
Group results for area of FAP up-regulation, perfusion defect, and mismatch between both …

Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging

B Xie, J Wang, XY Xi, X Guo, BX Chen, L Li… - European Journal of …, 2022 - Springer
Purpose The aim of this study was to explore the correlation of 18 F-labeled fibroblast
activation protein inhibitor (FAPI) and cardiovascular magnetic resonance (CMR) …