Spatial normalization of 18F-flutemetamol PET images using an adaptive principal-component template
Though currently approved for visual assessment only, there is evidence to suggest that
quantification of amyloid-β (Aβ) PET images may reduce interreader variability and aid in the …
quantification of amyloid-β (Aβ) PET images may reduce interreader variability and aid in the …
Implementation and validation of an adaptive template registration method for 18F-flutemetamol imaging data
The spatial normalization of PET amyloid imaging data is challenging because different
white and gray matter patterns of negative (Aβ−) and positive (Aβ+) uptake could lead to …
white and gray matter patterns of negative (Aβ−) and positive (Aβ+) uptake could lead to …
Optimal reference region to measure longitudinal amyloid-β change with 18F-Florbetaben PET
S Bullich, VL Villemagne, AM Catafau… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Accurate measurement of changes in amyloid-β (Aβ) deposition over time is important in
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …
Visualization and quantification of 3-dimensional stereotactic surface projections for 18F-Flutemetamol PET using variable depth
J Lilja, L Thurfjell, J Sörensen - Journal of Nuclear Medicine, 2016 - Soc Nuclear Med
Three-dimensional stereotactic surface projection (3D-SSP) is a widely used method for the
analysis of clinical 18F-FDG brain studies. However, for PET amyloid scans the use of 3D …
analysis of clinical 18F-FDG brain studies. However, for PET amyloid scans the use of 3D …
Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET
Purpose Amyloid positron emission tomography (PET) is an important noninvasive method
for detecting amyloid burden in Alzheimer's disease (AD) patients. As amyloid PET images …
for detecting amyloid burden in Alzheimer's disease (AD) patients. As amyloid PET images …
Improved power for characterizing longitudinal amyloid-β PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region
K Chen, A Roontiva, P Thiyyagura, W Lee… - Journal of Nuclear …, 2015 - Soc Nuclear Med
In this article, we describe an image analysis strategy with improved power for tracking
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: concordance with visual image reads
Clinical trials of the PET amyloid imaging agent 18F-flutemetamol have used visual
assessment to classify PET scans as negative or positive for brain amyloid. However …
assessment to classify PET scans as negative or positive for brain amyloid. However …
Early-phase 18F-Florbetapir and 18F-Flutemetamol images as proxies of brain metabolism in a memory clinic setting
Alzheimer disease (AD) neuropathologic changes are β-amyloid (Aβ) deposition, pathologic
tau, and neurodegeneration. Dual-phase amyloid PET might be able to evaluate Aβ …
tau, and neurodegeneration. Dual-phase amyloid PET might be able to evaluate Aβ …
[HTML][HTML] A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images
Background [18 F] flutemetamol PET scanning provides information on brain amyloid load
and has been approved for routine clinical use based upon visual interpretation as either …
and has been approved for routine clinical use based upon visual interpretation as either …
[HTML][HTML] rPOP: robust PET-only processing of community acquired heterogeneous amyloid-PET data
The reference standard for amyloid-PET quantification requires structural MRI (sMRI) for
preprocessing in both multi-site research studies and clinical trials. Here we describe rPOP …
preprocessing in both multi-site research studies and clinical trials. Here we describe rPOP …