A boron derived tyrosine mimic identifies cancer with positron emission tomography

J Li, Y Han, H Liu, Z Liu - 2018 - Soc Nuclear Med
1259 Objectives: Non-invasive diagnosis of cancer is a enormous challenge in clinics due to
the rising number of patients. A biopsy or surgery is often required to justify the malignancy …

A metabolically stable leucine mimic identifies cancer from inflammation with positron emission tomography

Z Liu, G Niu, D Kiesewetter, X Chen - 2016 - Soc Nuclear Med
1061 Objectives Non-invasively differentiating tumor from inflammation is a long-standing
challenge for cancer diagnosis. In clinics, a biopsy or surgery is often required to justify the …

A metabolically stable boron-derived tyrosine serves as a theranostic agent for positron emission tomography guided boron neutron capture therapy

J Li, Y Shi, Z Zhang, H Liu, L Lang, T Liu… - Bioconjugate …, 2019 - ACS Publications
Boronophenylalanine (BPA) is the dominant boron delivery agent for boron neutron capture
therapy (BNCT), and [18F] FBPA has been developed to assist the treatment planning for …

18F-Boramino Acids: Promising Traceable Amino Acid Mimics for Cancer Imaging

ZZ Liu, G Niu, D Kiesewetter, X Chen - 2015 - Soc Nuclear Med
222 Objectives The transportation of amino acids is known to be upregulated in many types
of tumor cells. Therefore, development of traceable amino acids for cancer imaging is of …

Novel Amino Acid Transporter-Targeted Radiotracers for Breast Cancer Imaging

FL Kong - 2011 - digitalcommons.library.tmc.edu
Breast cancer is the most common malignancy among women in the world. Its 5-year
survival rate ranges from 23.4% in patients with stage IV to 98% in stage I disease …

F-18 FPAMT: Automation, biodistribution and imaging of mesothelioma

D Yang, IH Shih, M Ali, DF Yu, FL Kong - 2012 - Soc Nuclear Med
136 Objectives Radiolabeled tyrosine analogs target up-regulated amino acid transport
system and have shown to be superior to FDG in differential diagnosis in cancers. This study …

Pilot Study of 18F-BF3-Tyr in Healthy Volunteers and Glioma Patients

Z Li, J Li, Z Yang, Z Liu - 2020 - Soc Nuclear Med
1216 Objectives: This work was designed to perform the very-first study of investigating the
safety, biodistribution, and radiation dosimetry of large amino acid transporter (LAT) …

18F-Boramino acid PET/CT in healthy volunteers and glioma patients

Z Li, Z Kong, J Chen, J Li, N Li, Z Yang, Y Wang… - European Journal of …, 2021 - Springer
Purpose In this work, the safety, biodistribution, and radiation dosimetry of large neutral
amino acid transporter type-1 (LAT-1) targeting PET tracer 18 F-trifluorobborate-derived …

A bis-boron boramino acid PET tracer for brain tumor diagnosis

Z Li, J Chen, Z Kong, Y Shi, M Xu, BS Mu, N Li… - European Journal of …, 2024 - Springer
Purpose Boramino acids are a class of amino acid biomimics that replace the carboxylate
group with trifluoroborate and can achieve the 18 F-labeled positron emission tomography …

Molecular biotheranostic approaches of cancers using LAT kit probes

FL Kong, DJ Yang, M Ali, M Tian… - Current Medical …, 2010 - ingentaconnect.com
Purpose: Positron emission tomography (PET) and single photon emission computed
tomography (SPECT) tracers have been applied to pharmacokinetic, pharmacodynamic …