Signaling pathways that drive 18F-FDG accumulation in cancer

JR Salas, PM Clark - Journal of Nuclear Medicine, 2022 - Soc Nuclear Med
18F-FDG measures glucose consumption and is an integral part of cancer management.
Most cancer types upregulate their glucose consumption, yielding elevated 18F-FDG PET …

[HTML][HTML] Revisit 18F-fluorodeoxyglucose oncology positron emission tomography:“systems molecular imaging” of glucose metabolism

B Shen, T Huang, Y Sun, Z Jin, XF Li - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography has become an
important tool for detection, staging and management of many types of cancer. Oncology …

A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography

TH Witney, L Carroll, IS Alam, A Chandrashekran… - Cancer research, 2014 - AACR
The high rate of glucose uptake to fuel the bioenergetic and anabolic demands of
proliferating cancer cells is well recognized and is exploited with 18F-2-fluoro-2-deoxy-d …

Oncogene pathway activation in mammary tumors dictates FDG-PET uptake

JV Alvarez, GK Belka, TC Pan, CC Chen… - Cancer research, 2014 - AACR
Increased glucose utilization is a hallmark of human cancer that is used to image tumors
clinically. In this widely used application, glucose uptake by tumors is monitored by positron …

Imaging cancer metabolism: underlying biology and emerging strategies

AR Pantel, D Ackerman, SC Lee… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Dysregulated cellular metabolism is a characteristic feature of malignancy that has been
exploited for both imaging and targeted therapy. With regard to imaging, deranged glucose …

18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

N Palaskas, SM Larson, N Schultz, E Komisopoulou… - Cancer research, 2011 - AACR
In contrast to normal cells, cancer cells avidly take up glucose and metabolize it to lactate
even when oxygen is abundant, a phenomenon referred to as the Warburg effect. This …

[HTML][HTML] Involvement of cancer-derived EMT cells in the accumulation of 18F-fluorodeoxyglucose in the hypoxic cancer microenvironment

S Sugita, M Yamato, T Hatabu, Y Kataoka - Scientific reports, 2021 - nature.com
A high rate of glycolysis, one of the most common features of cancer, is used in positron
emission tomography (PET) imaging to visualize tumor tissues using 18F …

[HTML][HTML] Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer

K Kawada, M Iwamoto, Y Sakai - World journal of radiology, 2016 - ncbi.nlm.nih.gov
Positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) is a diagnostic
tool to evaluate metabolic activity by measuring accumulation of FDG, an analogue of …

Does 2-FDG PET accurately reflect quantitative in vivo glucose utilization?

JR Barrio, SC Huang, N Satyamurthy… - Journal of Nuclear …, 2020 - Soc Nuclear Med
2-Deoxy-2-18F-fluoro-d-glucose (2-FDG) with PET is undeniably useful in the clinic, being
able, among other uses, to monitor change over time using the 2-FDG SUV metric. This …

[HTML][HTML] 18F-fluoro-2-deoxy-d-glucose (FDG) uptake. What are we looking at?

G Sambuceti, V Cossu, M Bauckneht, S Morbelli… - European Journal of …, 2021 - Springer
In the last decade, the possibility to map glucose consumption with 2-[18F] fluoro-2-deoxy-D-
glucose (FDG) imaging profoundly modified the daily activity of most nuclear medicine …