FAP: the next billion dollar nuclear theranostics target?
J Calais - Journal of Nuclear Medicine, 2020 - Soc Nuclear Med
The recent successful clinical translation of nuclear theranostics (1, 2) fueled industry
investment in the radiopharmaceutical market (3). Among other examples, Novartis invested …
investment in the radiopharmaceutical market (3). Among other examples, Novartis invested …
Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond
Fibroblast activation protein (FAP) is a type II membrane-bound glycoprotein which is
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
[HTML][HTML] Fibroblast activation protein-targeted radionuclide therapy: background, opportunities, and challenges of first (pre) clinical studies
BM Privé, MA Boussihmad, B Timmermans… - European journal of …, 2023 - Springer
Introduction Fibroblast activation protein (FAP) is highly overexpressed in stromal tissue of
various cancers. While FAP has been recognized as a potential diagnostic or therapeutic …
various cancers. While FAP has been recognized as a potential diagnostic or therapeutic …
Theranostics targeting fibroblast activation protein in the tumor stroma: 64Cu-and 225Ac-labeled FAPI-04 in pancreatic cancer xenograft mouse models
T Watabe, Y Liu, K Kaneda-Nakashima… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Fibroblast activation protein (FAP), which promotes tumor growth and progression, is
overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Because …
overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Because …
Initial clinical experience with 90Y-FAPI-46 radioligand therapy for advanced-stage solid tumors: a case series of 9 patients
J Ferdinandus, PF Costa, L Kessler… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in several solid tumors and therefore
represents an attractive target for radiotheranostic applications. Recent investigations …
represents an attractive target for radiotheranostic applications. Recent investigations …
Feasibility, biodistribution, and preliminary dosimetry in peptide-targeted radionuclide therapy of diverse adenocarcinomas using 177Lu-FAP-2286: first-in-humans …
RP Baum, C Schuchardt, A Singh… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of
numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which …
numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which …
68Ga-FAPI as a diagnostic tool in sarcoma: data from the 68Ga-FAPI PET prospective observational trial
L Kessler, J Ferdinandus, N Hirmas… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Bone and soft-tissue sarcomas express fibroblast activation protein (FAP) on tumor cells and
associated fibroblasts. Therefore, FAP is a promising therapeutic and diagnostic target …
associated fibroblasts. Therefore, FAP is a promising therapeutic and diagnostic target …
Targeting fibroblast activation protein: radiosynthesis and preclinical evaluation of an 18F-labeled FAP inhibitor
J Toms, J Kogler, S Maschauer, C Daniel… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in
the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP …
the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP …
[153Sm]Samarium-labeled FAPI-46 radioligand therapy in a patient with lung metastases of a sarcoma
C Kratochwil, FL Giesel, H Rathke, R Fink… - European Journal of …, 2021 - Springer
Fibroblast activation protein is overexpressed by cancerassociated fibroblasts (CAFs) in the
stroma of several tumor entities and provides anti-immunogenic effects [1]. It can be targeted …
stroma of several tumor entities and provides anti-immunogenic effects [1]. It can be targeted …
FAPI PET: fibroblast activation protein inhibitor use in oncologic and nononcologic disease
Y Mori, K Dendl, J Cardinale, C Kratochwil, FL Giesel… - Radiology, 2023 - pubs.rsna.org
Gallium 68 (68Ga)–labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based
on the molecular targeting of the FAP, which is known to be highly expressed in the major …
on the molecular targeting of the FAP, which is known to be highly expressed in the major …