Human PET studies of the norepinephrine transporter (NET) with (S, S)-[11C] O-methyl reboxetine ([11C](S, S)-MRB) and PET
203 Objectives: Human studies with [11C](S, S)-MRB, a NET radiotracer, were done to
assess regional distribution, kinetics, reproducibility and sensitivity to blockade with the high …
assess regional distribution, kinetics, reproducibility and sensitivity to blockade with the high …
Imaging the norepinephrine transporter in humans with (S, S)-[11C] O-methyl reboxetine and PET: problems and progress
Results from human studies with the PET radiotracer (S, S)-[11C] O-methyl reboxetine
([11C](S, S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported …
([11C](S, S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported …
Radiosynthesis and microPET evaluation of (S, S)-6-F-[11C] methylreboxetine and (S, S)-3-F-[11C] methylreboxetine as norepinephrine transporter imaging agents
F Zeng, J Mun, J Nye, W Yu, R Voll, L Howell… - 2014 - Soc Nuclear Med
1817 Objectives Attempts to image the norepinephrine transporter (NET) in living systems
with PET have so far met with limited success due to the lack of effective radioligands.(S, S) …
with PET have so far met with limited success due to the lack of effective radioligands.(S, S) …
Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
The development of positron emission tomography (PET) ligands for the norepinephrine
transporter (NET) has been slow compared to the development of radiotracers for others …
transporter (NET) has been slow compared to the development of radiotracers for others …
Evaluation of [11C] MRB for assessment of occupancy of norepinephrine transporters: studies with atomoxetine in non-human primates
[11C] MRB is one of the most promising radioligands used to measure brain norepinephrine
transporters (NET) with positron emission tomography (PET). The objective of this study was …
transporters (NET) with positron emission tomography (PET). The objective of this study was …
18F-Labeled analogs of reboxetine as PET imaging agents for norepinephrine transporters
F Zeng, N Jarkas, J Stehouwer, L Williams, J Votaw… - 2007 - Soc Nuclear Med
1335 Objectives: The development of radioligands to map the norepinephrine transporter
(NET) by positron emission tomography (PET) techniques presents unique opportunities to …
(NET) by positron emission tomography (PET) techniques presents unique opportunities to …
Synthesis and evaluation of a C-11 labeled reboxetine analog as a norepinephrine transporter imaging agent
F Zeng, N Jarkas, J Stehouwer, R Voll, M Owens… - 2006 - Soc Nuclear Med
1821 Objectives: The norepinephrine transporter (NET), a specific marker of noradrenergic
neurons, has been recognized in the involvement of several neurological and psychiatric …
neurons, has been recognized in the involvement of several neurological and psychiatric …
In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter
AJ Severance, MS Milak, JSD Kumar… - European Journal of …, 2007 - Springer
Purpose Antagonism of norepinephrine reuptake is now an important pharmacological
strategy in the treatment of anxiety and depressive disorders, and many antidepressants …
strategy in the treatment of anxiety and depressive disorders, and many antidepressants …
An open-label, randomized positron emission tomography (PET) study in healthy male volunteers consisiting of Part A and Part B. Part A: Clinical validation of …
J Fowler, M Furey - 2007 - osti.gov
Results from human studies with the PET radiotracer (S, S)-[(11) C] O-methyl reboxetine
([(11) C](S, S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported …
([(11) C](S, S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported …
Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[18F]FMeNER-D2
A Takano, B Gulyás, A Varrone, RP Maguire… - European journal of …, 2009 - Springer
Purpose In a previous PET study on norepinephrine transporter (NET) occupancy in the
nonhuman primate brain, the relationship between NET occupancy and atomoxetine plasma …
nonhuman primate brain, the relationship between NET occupancy and atomoxetine plasma …