The identification of new molecular targets for diagnostic and therapeutic applications using
in vitro methods is an important challenge in nuclear medicine. One such method is …

Mapping of receptor binding to specific structures, or cells within tissue samples, provides
valuable information regarding biological and pathological mechanisms. Such information …

Targeting specific cell membrane markers for both diagnostic imaging and radionuclide
therapy is a rapidly evolving field in cancer research. Some of these applications have now …

The growing understanding of tumor biology and the identification of tumor‐specific genetic
and molecular alterations, such as the overexpression of membrane receptors and other …

Both radiolabeled ligands to specific receptors on cell surfaces and radiolabeled antibodies
to specific cell surface epitopes provide new opportunities to scintigraphically identify …

Modern drug discovery highly depends on the identification and validation of the drug
targets. Using the method of in vitro quantitative receptor autoradiography, we demonstrated …

Conclusion The critical choice in molecular targeting is to select a target that will have an
impact on patient management. Given the large number of targets that are often associated …

The G-protein coupled receptor system is involved in a range of cell types and actions and
as such has a universal potential in identifying cell functions. The most widely explored …

Validation of a new radioligand using the pharmacologic definition of a receptor-binding
radiotracer can be a long process [1, 2] and is not commensurate with the fast-paced …

Most modern drug therapies function by interaction with a defined molecular target that is
present, often at enhanced levels. in the disease state for which the therapy is intended. The …