MISO in vitro into EMT6 cells was investigated at the dissolved oxygen concentrations of 0, 1
x to3, 5 x 103, 5 x 10" and 2 x 105 ppm. Biodistribution performed at 1, 5, 10, 20 and 40 min …

BACKGROUND: Cu-diacetyl-bis (N4-methylthiosemicarbazone)[Cu-ATSM] is a potential
marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we …

Tumor hypoxia is recognized as an important determinant of response to therapy. In this
study we investigated the feasibility of clinical imaging with copper-60 diacetyl-bis (N 4 …

64Cu-diacetyl-bis (N4-methylthiosemicarbazone)(64Cu-ATSM) is a promising radiotherapy
agent for the treatment of hypoxic tumors. In an attempt to elucidate the radiobiological basis …

We compared the imaging characteristics and hypoxia selectivity of 4 hypoxia PET
radiotracers (18F-fluoromisonidazole [18F-FMISO], 18F-flortanidazole [18F-HX4], 18F …

Purpose Cu-diacetyl-bis (N 4-methylthiosemicarbazone (Cu-ATSM) is an effective marker for
the delineation of hypoxic tissue. Dosimetry calculations by the established Medical Internal …

Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …

During the carcinogenesis process, tumour cells often have a more rapid proliferation
potential than cells that participate in blood capillary formation by neoangiogenesis. As a …

Abstract 62 Cu labeled diacetyl-bis (N 4-methylthiosemicarbazone)(62 Cu-ATSM) has been
proposed as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From …

For the last several decades, hypoxia has been recognized to be one of the key factors in
tumor aggression and an important impediment to local and distant control of malignant …