On the destiny of (copper) species
JLJ Dearling, AB Packard - Journal of Nuclear Medicine, 2014 - Soc Nuclear Med
The study by Hueting et al.(1) in this issue of The Journal of Nuclear Medicine reporting the
biodistribution of the putative hypoxia tracer 64Cu-diacetyl-bis (N4 …
biodistribution of the putative hypoxia tracer 64Cu-diacetyl-bis (N4 …
A comparison of the behavior of 64Cu-acetate and 64Cu-ATSM in vitro and in vivo
R Hueting, V Kersemans, B Cornelissen… - Journal of Nuclear …, 2014 - Soc Nuclear Med
64Cu-diacetyl-bis (N 4-methylthiosemicarbazonate), 64Cu-ATSM, continues to be
investigated clinically as a PET agent both for delineation of tumor hypoxia and as an …
investigated clinically as a PET agent both for delineation of tumor hypoxia and as an …
Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM
P Burgman, JA O'Donoghue, JS Lewis… - Nuclear medicine and …, 2005 - Elsevier
BACKGROUND: Cu-diacetyl-bis (N4-methylthiosemicarbazone)[Cu-ATSM] is a potential
marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we …
marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we …
64Cu-ATSM is metabolised rapidly in vivo to yield circulating 64Cu2+ in blood in the mouse
R Hueting, V Kersemans, M Tredwell, K Hussien… - 2011 - Soc Nuclear Med
238 Objectives 64 Cu-diacetyl-bis (N 4-methylthiosemicarbazone)(CuATSM) is increasingly
used to identify hypoxic tumours for diagnosis and treatment planning. We have examined …
used to identify hypoxic tumours for diagnosis and treatment planning. We have examined …
64Cu-ATSM reflects pO2 levels in human head and neck cancer xenografts but not in colorectal cancer xenografts: comparison with 64CuCl2
F Li, JT Jørgensen, J Forman… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The hypoxia PET tracer 64Cu-diacetyl-bis (N 4-methylthiosemicarbazonate)(64Cu-ATSM)
has shown promising results in clinical studies. However, concerns have been raised with …
has shown promising results in clinical studies. However, concerns have been raised with …
Copper-64-diacetyl-bis (N (4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia
PURPOSE: The behavior of copper-64-diacetyl-bis (N (4)-methylthiosemicarbazone)(64Cu-
ATSM) in hypoxic tumors was examined through a combination of in vivo dynamic positron …
ATSM) in hypoxic tumors was examined through a combination of in vivo dynamic positron …
An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
Tumor uptake of copper (II)-diacetyl-bis (N 4-methylthiosemicarbazone)(copper-ATSM), a
hypoxia-targeting radiopharmaceutical, assessed by PET has been found to correlate with …
hypoxia-targeting radiopharmaceutical, assessed by PET has been found to correlate with …
[HTML][HTML] Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention …
T Liu, M Karlsen, AM Karlberg, KR Redalen - EJNMMI research, 2020 - Springer
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …
tumor environment, associated with malignant progression, radiotherapy resistance, and …
Tumor uptake of copper-diacetyl-bis (N4-methylthiosemicarbazone): effect of changes in tissue oxygenation
JS Lewis, TL Sharp, R Laforest… - Journal of Nuclear …, 2001 - Soc Nuclear Med
We showed previously that, in vitro, copper-diacetyl-bis (N 4-methylthiosemicarbazone)(Cu-
ATSM) uptake is dependent on the oxygen concentration (pO2). We also showed that, in …
ATSM) uptake is dependent on the oxygen concentration (pO2). We also showed that, in …
Evaluation of62Cu labeled diacetyl-bis(N 4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer
N Takahashi, Y Fujibayashi, Y Yonekura… - Annals of nuclear …, 2000 - Springer
Abstract 62 Cu labeled diacetyl-bis (N 4-methylthiosemicarbazone)(62 Cu-ATSM) has been
proposed as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From …
proposed as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From …
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