1556 Objectives To identify the optimal antibody format for PET detection of neuroblastoma.
Methods Whole IgG ch14. 18 (150 kDa) and its ΔC H 2 (120 kDa) and scFv-Fc (100 kDa) …

1356 Objectives: The following hypothesis was tested: Copper-64-labeled ch14. 18-deltaC
H 2 (MW 120 kDa) has improved imaging properties compared with its parent IgG (ch14. 18 …

498 Objectives Neuroblastoma (NB) patients frequently relapse with widespread disease.
Liver is a common site of metastatic spread, and the characterization of these metastases …

Background: Antibodies targeting surface expressed disialoganglioside GD2 are
increasingly used in neuroblastoma immunotherapy and might also have potential for use in …

375 Objectives The biodistribution of the anti-GD2 antibody ch14. 18 labeled with Cu-64
using 5 bifunctional chelators (BFCs) was measured to determine which provided optimal …

Overall, small molecules and antibodies were radiolabeled for potential applications of
diagnostic imaging in small animals. The 4FN precursor was successfully synthesized and …

Purpose Recombinant antibodies isolated from human antibody libraries have excellent
affinities and high target specificity. As full-length IgGs are cleared inadequately slowly from …

1035 Introduction: Malignant gliomas are the most common primary central nervous system
tumor with over 12,000 newly diagnosed cases each year in the United States. As up to 30 …

1564 Objectives: Monitoring temporal change of antibody uptake distribution by means of
SPECT is important for evaluation of characteristics of antibody in animal study. Radioiodine …

Abstract Purpose The∼ 15 kDa variable domains of camelid heavy-chain-only antibodies
(called Nanobodies®) have the flexibility to be formatted as monovalent, monospecific …