Imaging non-coding microRNA upregulation in pressure overload heart failure using the complementary anti-miR-21 locked nucleic acid
J Thackeray, E Janssen, A Glasenapp, J Fiedler… - 2021 - Soc Nuclear Med
138 Objectives: Non-coding ribonucleic acids (RNA) are upregulated in heart failure, during
which they modulate ventricle remodeling. Selective inhibitors of microRNA-21 (miR-21) …
which they modulate ventricle remodeling. Selective inhibitors of microRNA-21 (miR-21) …
Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo
N Abbas, JA Haas, K Xiao, M Fuchs, A Just… - European Heart …, 2024 - academic.oup.com
MicroRNA-21 (miR-21) plays a significant role in the regulation of fibrotic and inflammatory
gene expression signatures. Endogenous miR-21 shows robust expression in different types …
gene expression signatures. Endogenous miR-21 shows robust expression in different types …
[HTML][HTML] miRNAs to the rescue: Reversing heart failure by targeting miR-29
X Wang, I Anwar, CP Hodgkinson - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Heart failure is a condition whereby the heart is unable to pump enough blood to meet the
body's needs. Commonly, heart failure arises from damage to the heart muscle. Heart …
body's needs. Commonly, heart failure arises from damage to the heart muscle. Heart …
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
BC Bernardo, XM Gao, CE Winbanks… - Proceedings of the …, 2012 - National Acad Sciences
MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising
therapeutic targets. MicroRNA-34 family members (miR-34a,-34b, and-34c) are up …
therapeutic targets. MicroRNA-34 family members (miR-34a,-34b, and-34c) are up …
[HTML][HTML] miRNA-based therapeutics for heart failure: why not?
JS Hulot, N Masurkar - Journal of the American College of Cardiology, 2020 - jacc.org
Gene therapy has the potential to revolutionize treatment outcomes for various diseases (1),
and micro–ribonucleic acids (miRNAs) are at the forefront of the race to treat debilitating …
and micro–ribonucleic acids (miRNAs) are at the forefront of the race to treat debilitating …
Inhibition of Microrna-21 Prevents Myocardial Remodelling and Dysfunction in a Pig Model of Ischemia/reperfusion Injury
DP Ramanujam, R Hinkel, V Kazcmarek… - Circulation …, 2018 - Am Heart Assoc
Background: Upregulation of microRNA-21 (miR-21) has been associated with myocardial
disease and its systemic inhibition was effective in reducing cardiac fibrosis and dysfunction …
disease and its systemic inhibition was effective in reducing cardiac fibrosis and dysfunction …
Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
RL Montgomery, TG Hullinger, HM Semus… - Circulation, 2011 - Am Heart Assoc
Background—Diastolic dysfunction in response to hypertrophy is a major clinical syndrome
with few therapeutic options. MicroRNAs act as negative regulators of gene expression by …
with few therapeutic options. MicroRNAs act as negative regulators of gene expression by …
AntimiR-21 prevents myocardial dysfunction in a pig model of ischemia/reperfusion injury
R Hinkel, D Ramanujam, V Kaczmarek, A Howe… - Journal of the American …, 2020 - jacc.org
Background miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-
animal models has been shown to be an effective antifibrotic strategy in various organs …
animal models has been shown to be an effective antifibrotic strategy in various organs …
The therapeutic potential of microRNA-652 for the treatment of heart failure
Methods: Mice were subjected to transverse aortic constriction (TAC) for four weeks to
induce hypertrophy and systolic dysfunction, then subcutaneously administered a locked …
induce hypertrophy and systolic dysfunction, then subcutaneously administered a locked …
miR-25 in heart failure
EW Bush, E van Rooij - Circulation research, 2014 - Am Heart Assoc
Bush and van Rooij miR-25 in Heart Failure 611 their anti-miR against miR-122, miravirsen,
in humans. These data indicated that miravirsen given as a 4-week monotherapy to hepatitis …
in humans. These data indicated that miravirsen given as a 4-week monotherapy to hepatitis …