In vivo evaluation of six analogs of 11C-ER176 as candidate 18F-labeled radioligands for translocator protein 18 kDa (TSPO)

JH Lee, F Simeon, JS Liow, C Morse, R Gladding… - 2021 - Soc Nuclear Med
1 Objectives: 11 C-ER176 can successfully image TSPO, a biomarker of inflammation, in
human brain because it has an excellent ratio of specific to nondisplaceable uptake and can …
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In Vivo Evaluation of 6 Analogs of 11C-ER176 as Candidate 18F-Labeled Radioligands for 18-kDa Translocator Protein

JH Lee, FG Siméon, JS Liow, CL Morse… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
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[HTML][HTML] In vivo evaluation of a novel 18F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain

X Yan, FG Siméon, JS Liow, CL Morse… - European Journal of …, 2023 - Springer
Abstract Purpose [18F] SF51 was previously found to have high binding affinity and
selectivity for 18 kDa translocator protein (TSPO) in mouse brain. This study sought to …
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11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain

M Ikawa, TG Lohith, S Shrestha, S Telu… - Journal of Nuclear …, 2017 - Soc Nuclear Med
For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation,
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
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In vivo evaluation of a novel 18F-labeled PET radioligand for translocator protein 18kDa (TSPO) in monkey brain

X Yan, FG Siméon, JS Liow, CL Morse… - 2022 - researchsquare.com
Purpose: 18 F-SF51 was previously found to have high binding affinity and selectivity for
18kDa translocator protein (TSPO) in mouse brain. This study sought to further evaluate the …
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Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, 18F-PBR06

Y Fujimura, SS Zoghbi, FG Simeon… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Translocator protein (TSPO)(18 kDa), formerly called the peripheral benzodiazepine
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …
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Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand

FG Siméon, JH Lee, CL Morse, I Stukes… - Journal of medicinal …, 2021 - ACS Publications
Translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation.[11C] ER176
robustly quantifies TSPO in the human brain with positron emission tomography (PET) …
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Flutriciclamide (18F-GE180) PET: first-in-human PET study of novel third-generation in vivo marker of human translocator protein

Z Fan, V Calsolaro, RA Atkinson… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Neuroinflammation is associated with neurodegenerative disease. PET radioligands
targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of …
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Optimized quantification of translocator protein radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers

S Lavisse, D García-Lorenzo… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated
during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO …
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[HTML][HTML] Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F] LW223 as a TSPO-targeted PET …

Z Tan, A Haider, S Zhang, J Chen, J Wei, K Liao… - Pharmacological …, 2023 - Elsevier
Abstract Objectives Translocator protein 18 kDa (TSPO) positron emission tomography
(PET) can be harnessed for the non-invasive detection of macrophage-driven …
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