In Vivo Evaluation of 6 Analogs of 11C-ER176 as Candidate 18F-Labeled Radioligands for 18-kDa Translocator Protein
JH Lee, FG Siméon, JS Liow, CL Morse… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of …
11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain
M Ikawa, TG Lohith, S Shrestha, S Telu… - Journal of Nuclear …, 2017 - Soc Nuclear Med
For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation,
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
Alternative strategies for the synthesis of [11C] ER176 for PET imaging of neuroinflammation
JC Mixdorf, D Murali, Y Xin, AH DiFilippo… - Applied Radiation and …, 2021 - Elsevier
Abstract [11 C] ER176 is a next generation PET radioligand for imaging 18 kDa translocator
protein, a biomarker for neuroinflammation. The goal of this work was to investigate …
protein, a biomarker for neuroinflammation. The goal of this work was to investigate …
Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, 18F-PBR06
Y Fujimura, SS Zoghbi, FG Simeon… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Translocator protein (TSPO)(18 kDa), formerly called the peripheral benzodiazepine
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …
Development of a 18F-Labeled Radiotracer with Improved Brain Kinetics for Positron Emission Tomography Imaging of Translocator Protein (18 kDa) in Ischemic …
M Fujinaga, R Luo, K Kumata, Y Zhang… - Journal of Medicinal …, 2017 - ACS Publications
We designed four novel acetamidobenzoxazolone compounds 7a–d as candidates for
positron emission tomography (PET) radiotracers for imaging the translocator protein (18 …
positron emission tomography (PET) radiotracers for imaging the translocator protein (18 …
Flutriciclamide (18F-GE180) PET: first-in-human PET study of novel third-generation in vivo marker of human translocator protein
Z Fan, V Calsolaro, RA Atkinson… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Neuroinflammation is associated with neurodegenerative disease. PET radioligands
targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of …
targeting the 18-kDa translocator protein (TSPO) have been used as in vivo markers of …
In vivo quantification of cerebral translocator protein binding in humans using 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] pyridine-3-acetamide …
This study provides the first comprehensive quantification of translocator protein (TSPO)
binding using SPECT and 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] …
binding using SPECT and 6-chloro-2-(4′-123I-iodophenyl)-3-(N, N-diethyl)-imidazo [1, 2-a] …
Optimized quantification of translocator protein radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers
S Lavisse, D García-Lorenzo… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated
during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO …
during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO …
Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand
FG Siméon, JH Lee, CL Morse, I Stukes… - Journal of medicinal …, 2021 - ACS Publications
Translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation.[11C] ER176
robustly quantifies TSPO in the human brain with positron emission tomography (PET) …
robustly quantifies TSPO in the human brain with positron emission tomography (PET) …
[HTML][HTML] Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F] LW223 as a TSPO-targeted PET …
Abstract Objectives Translocator protein 18 kDa (TSPO) positron emission tomography
(PET) can be harnessed for the non-invasive detection of macrophage-driven …
(PET) can be harnessed for the non-invasive detection of macrophage-driven …
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