The purpose of this paper is to explore the implica tions ofthe distribution ofradiolabeled Ab
in the tumor on the microdosimetry, ie, the energy deposition at the cellular level. This paper …

In the context of radioimmunotherapy of cancer, there is a need for continued improvement
of dosimetry of radionuclides localized in tumors. Current methods assume uniform …

Tumor therapy using radiolabeled antibodies presents a challenging problem in absorbed
dose determination. The purpose of this study is to evaluate the effect of tumor size on the …

Radioimmunotherapy (AlT) is rapidly attracting interest as a potential new weapon in the
arsenal for cancer therapy. This article concentrates on some of the dosimetnc aspects …

Absorbed fractions (@) were calculated for spheres that ranged in diameter from 20@ mto
4.4 cm. The details of the computa tional procedure used have been reported elsewhere (8) …

Calculational methods of beta‐particle dosimetry in radioimmunotherapy (RIT) are reviewed
for clinical and experimental studies and computer modeling of tumors. In clinical studies …

Inhomogeneities in activity distributions over distances from 10 to 104 μm are observed in
many tumors treated with radiolabeled antibodies. Resulting nonuniformities in absorbed …

In microdosimetry particular emphasis is placed on the stochastic fluctuation of dose in small
target volumes such as individual cell nuclei or chromatin fiber, and their relevance to …

Radiolabeled monoclonal antibodies have been used for radioimmunotherapy studies with
human tumor spheroids and murine and human tumor xenografts in experimental animals …

Three-dimensional dose distributions have been calculated for LS174T human colon cancer
xenografts in athymic nude mice treated with 131 I-labeled 174A monoclonal antibody …