In vivo estimation of β2-nicotinic acetylcholine receptor availability with molecular
neuroimaging is complicated by competition between the endogenous neurotransmitter …

Iodo-3-(2 (S)-azetidinylmethoxy) pyridine (5IA), an A-85380 analog iodinated at the 5-
position of the pyridine ring, was evaluated as a radiopharmaceutical for investigating brain …

The iodinated analog (S)-5-[123I] iodo-3-(2-azetidinylmethoxy) pyridine of A-85380 is a new
potential SPECT tracer specific for the α4β2 subtype nicotinic acetylcholine receptors, which …

Nicotinic acetylcholine receptors (nAChRs) play an important role in tobacco dependence
and a potential therapeutic role in neuropsychiatricdisorders such as Alzheimer's …

Tomographic imaging of central nicotinic acetylcholine receptors (nAChRs) via single
photon emission computed tomography (SPECT) has been hampered by the lack of a …

Abstract A novel radioligand, 6‐chloro‐3‐((2‐(S)‐azetidinyl) methoxy)‐5‐(2‐fluoropyridin‐4‐
yl) pyridine (NIDA522131), for imaging extrathalamic nicotinic acetylcholine receptors …

A radiosynthetic method to prepare the nicotinic acetylcholine receptor radioligand (S)-5-
[123I] iodo-3-(2-azetidinylmethoxy) pyridine, 5-IA, has been developed. The two-step …

[125 I] iodo-3-(2 (S)-azetidinylmethoxy) pyridine ([125 I] 5-IA-85380) was evaluated in the
mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors …

123I-5-IA-85380 (123I-5-IA;[123I]-5-iodo-3-[2 (S)-azetidinylmethoxy] pyridine) is a promising
SPECT radiotracer for imaging β2-containing nicotinic acetylcholine receptors (β2-nAChRs) …

INTRODUCTION: Some in vitro investigations have suggested that the nicotinic
acetylcholine receptor (nAChR) α7 subtype is implicated in Alzheimer's disease …