First clinical results of (d)-18f-fluoromethyltyrosine (bay 86-9596) pet/ct in patients with non–small cell lung cancer and head and neck squamous cell carcinoma

IA Burger, S Zitzmann-Kolbe, J Pruim… - Journal of Nuclear …, 2014 - Soc Nuclear Med
(d)-18F-fluoromethyltyrosine (d-18F-FMT), or BAY 86-9596, is a novel 18F-labeled tyrosine
derivative rapidly transported by the l-amino acid transporter (LAT-1), with a faster blood …

18F-FMT uptake seen within primary cancer on PET helps predict outcome of non–small cell lung cancer

K Kaira, N Oriuchi, K Shimizu, H Tominaga… - Journal of Nuclear …, 2009 - Soc Nuclear Med
L-[3-18F]-α-methyl tyrosine (18F-FMT) is an amino-acid tracer for PET imaging. We
evaluated the prognostic significance of 18F-FMT PET in patients with non–small cell lung …

Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

A Nobusawa, M Kim, K Kaira, G Miyashita… - European journal of …, 2013 - Springer
Abstract Purpose l-[3-18 F]-α–Methyltyrosine (18 F-FAMT) was developed as an amino acid
tracer for PET imaging to provide better specificity than 2-[18 F] fluoro-2-deoxy-d-glucose (18 …

PET with O-(2-18F-fluoroethyl)-L-tyrosine in peripheral tumors: first clinical results

D Pauleit, G Stoffels, W Schaden… - Journal of Nuclear …, 2005 - Soc Nuclear Med
O-(2-18F-Fluoroethyl)-l-Tyrosine (18F-FET) PET has shown promising results in brain tumor
diagnosis. The aim of this prospective study was to evaluate 18F-FET PET in comparison …

Whole-body tumor imaging using PET and 2-18F-fluoro-L-tyrosine: preliminary evaluation and comparison with 18F-FDG

R Hustinx, C Lemaire, G Jerusalem… - Journal of Nuclear …, 2003 - Soc Nuclear Med
18F-FDG PET imaging is now established as a valuable tool for evaluating cancer patients.
However, a limitation of 18F-FDG is its absence of specificity for tumor. Both protein …

Evaluation of O-[18F] fluoromethyl-d-tyrosine as a radiotracer for tumor imaging with positron emission tomography

T Urakami, K Sakai, T Asai, D Fukumoto… - Nuclear medicine and …, 2009 - Elsevier
O-[18F] Fluoromethyl-d-tyrosine (d-[18F] FMT) has been reported as a potential tumor-
detecting agent for positron emission tomography (PET). However, the reason why d-[18F] …

Evaluation of thoracic tumors with 18F‐FMT and 18F‐FDG PET‐CT: A clinicopathological study

K Kaira, N Oriuchi, K Shimizu, T Ishikita… - … Journal of Cancer, 2009 - Wiley Online Library
Abstract L‐[3‐18F]‐α‐methyltyrosine (18F‐FMT) is an aminoacid tracer for positron emission
tomography (PET). The aim of this study was to determine whether PET‐CT with 18F‐FMT …

Fluorine-18-α-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study

K Kaira, N Oriuchi, Y Otani, K Shimizu, S Tanaka… - Clinical Cancer …, 2007 - AACR
Abstract Purpose: l-[3-18F]-α-Methyltyrosine ([18F] FMT) is an amino acid tracer for positron
emission tomography (PET). We evaluated the diagnostic usefulness of [18F] FMT PET in …

Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET

P Wiriyasermkul, S Nagamori… - Journal of Nuclear …, 2012 - Soc Nuclear Med
l-3-18F-α-methyl tyrosine (18F-FAMT) has been developed as a PET radiotracer for tumor
imaging. Clinical studies have demonstrated the usefulness of 18F-FAMT PET for the …

18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry

G Miyashita, T Higuchi, N Oriuchi, Y Arisaka… - Annals of nuclear …, 2010 - Springer
Abstract Objective l-3-[18 F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells
by l-type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate …